Pulmonary function measures as predictors and correlates of cognitive functioning in later life.
Pulmonary function measures as predictors and correlates of cognitive functioning in later life.
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DOI：
10.1093/oxfordjournals.aje.a008812
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发表时间：
1996-04
影响因子：
5
通讯作者：
P. Chyou;L. White;K. Yano;D. Sharp;C. Burchfiel;Randi Chen;B. Rodríguez;J. Curb
中科院分区：
文献类型：
--
作者：
P. Chyou;L. White;K. Yano;D. Sharp;C. Burchfiel;Randi Chen;B. Rodríguez;J. Curb
研究对象为居住在夏威夷的3,036名日裔美国男性，研究对象为肺功能和认知功能之间的关系。在1965年至1968年的基线检查中测量肺功能，以1秒用力呼气量（FEV 1）表示。至少23年后（1991-1993年），通过认知能力筛查工具（CASI）测试评估认知功能。基线FEV 1与随访CASI评分显著相关（r = 0.22，p = 0.0001）。虽然通过控制其他因素的影响，这种关联的强度降低了，但逐步多元线性回归显示，在考虑了年龄、教育、中风、久坐不动的工作活动、非体力职业、身高、世代和日语能力的影响后，中年时期的FEV 1是晚年CASI的一个重要预测因素。与FEV 1水平处于最低（<2.5升）四分位数的男性相比，FEV 1超过2.8升的男性的平均CASI值显著更大。此外，对FEV 1与年龄之间相互作用影响的检验具有统计学显著性（p = 0.0024），基线检查时年龄小于55岁的受试者显示FEV 1与CASI的直接相关性强于55岁或以上的男性。这些发现表明肺功能损害可能与以后生活中的认知功能损害有关。
The relation between pulmonary function and cognitive functioning was investigated in a cohort of 3,036 Japanese-American men living in Hawaii. Pulmonary function, as indicated by forced expiratory volume in 1 second (FEV1), was measured at the baseline examination from 1965 to 1968. Cognitive function was assessed by the Cognitive Abilities Screening Instrument (CASI) test at least 23 years later (1991-1993). Baseline FEV1 was significantly correlated with follow-up CASI score (r = 0.22, p = 0.0001). Although the strength of the association was reduced by controlling for the effects of other factors, stepwise multiple linear regression showed that FEV1 during middle age was a significant predictor of CASI in later life, after taking into account the effects of age, education, stroke, sedentary job activity, nonmanual occupation, height, generation, and Japanese speaking ability. The mean CASI value was significantly greater for men whose FEV1 exceeded 2.8 liter compared with those whose FEV1 levels were in the lowest (<2.5 liters) quartile. Furthermore, the test on the effect of interaction between FEV1 and age was statistically significant (p = 0.0024), with subjects less than 55 years of age at the baseline examination showing a stronger direct association of FEV1 with CASI than the men aged 55 or older. These findings suggest that pulmonary function impairment may be associated with cognitive function impairment in later life.