A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
复制标题
BVDU 的胸苷磷酸化酶稳定类似物，具有显着的抗病毒活性。
DOI：
10.1021/jm025569k
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发表时间：
2002
影响因子：
7.3
通讯作者：
Nair,Vasu
中科院分区：
文献类型：
--
作者：
Guenther,Sven;Balzarini,Jan;DeClercq,Erik;Nair,Vasu
(E)-5-(2-Bromovinyl)isodideoxyuridine (BVisoDDU), synthesized on the basis of molecular modeling, is selectively active against HSV-1 (three different strains) but inactive against HSV-2. Unlike BVDU, BVisoDDU is completely resistant to cleavage by thymidine phosphorylase. BVisoDDU is also the first nucleoside analogue lacking OH groups at both the 2‘- and 3‘-position that shows pronounced activity against HSV-1 replication.
