The SUMMIT Trial A field comparison of buprenorphine versus methadone maintenance treatment
The SUMMIT Trial A field comparison of buprenorphine versus methadone maintenance treatment
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DOI：
10.1016/j.jsat.2010.07.009
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发表时间：
2010-12-01
影响因子：
3.9
通讯作者：
Holland, Richard
中科院分区：
文献类型：
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作者：
Pinto, Hayley;Maskrey, Vivienne;Holland, Richard
这项前瞻性患者偏好研究考察了美沙酮与丁丙诺啡维持治疗实践中的有效性以及受试者对这些药物的信念。共有 361 名阿片类药物依赖者（其中 89% 符合资格，在英格兰药物服务机构接受治疗超过 2 年）接受了美沙酮或丁丙诺啡的快速滴定，然后灵活剂量，227 名患者选择了美沙酮 (63%) 和 134 名丁丙诺啡(37%) 选择美沙酮的参与者有更严重的药物滥用以及精神和身体问题，但更有可能继续接受治疗 生存分析表明，那些服用美沙酮的参与者保留治疗的可能性是其两倍以上（美沙酮与丁丙诺啡相比，保留的风险比为 2 08，95% 置信区间 [CI] = 1 49-2 94），但是，保留服用丁丙诺啡的参与者更有可能抑制非法阿片类药物使用（比值比 = 2 136，95% CI = 1 509-3 027，p < 001）并实现戒毒 丁丙诺啡还可能招募更多个体接受治疗，因为选择丁丙诺啡的人中 28%（占总样本的 10%）表示他们不会接受美沙酮治疗 (c) 2010 Elsevier Inc 保留所有权利
This prospective patient-preference study examined the effectiveness in practice of methadone versus buprenorphine maintenance treatment and the beliefs of subjects regarding these drugs A total of 361 opiate-dependent individuals (89% of those eligible, presenting for treatment over 2 years at a drug service in England) received rapid titration then flexible dosing with methadone or buprenorphine, 227 patients chose methadone (63%) and 134 buprenorphine (37%) Participants choosing methadone had more severe substance abuse and psychiatric and physical problems but were more likely to remain in treatment Survival analysis indicated those prescribed methadone were over twice as likely to be retained (hazard ratio for retention was 2 08 and 95% confidence interval [CI] = 1 49-2 94 for methadone vs buprenorphine), However, those retained on buprenorphine were more likely to suppress illicit opiate use (odds ratio = 2 136, 95% CI = 1 509-3 027,p < 001) and achieve detoxification Buprenorphine may also recruit more individuals to treatment because 28% of those choosing buprenorphine (10% of the total sample) stated they would not have accessed treatment with methadone (c) 2010 Elsevier Inc All rights reserved