Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging
Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging
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DOI：
10.1177/088307380101600902
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发表时间：
2001-09-01
影响因子：
1.9
通讯作者：
Moore, GJ
中科院分区：
文献类型：
--
作者：
Rosenberg, DR;Amponsah, A;Moore, GJ
丘脑与强迫症的病理生理有关。使用多层光谱成像序列，我们报告了11例8 - 15岁的强迫症患儿与11例病例匹配的健康对照组的右侧和左侧内侧丘脑N-乙酰天冬氨酸/胞浆胆碱+肌酸/磷酸肌酸和N-乙酰天冬氨酸/胞浆胆碱水平的降低。这些变化可能反映了N-乙酰天冬氨酸、胞质胆碱或肌酸浓度的变化。因此，使用经验证的体模替换方法，我们获得了N-乙酰天冬氨酸的绝对测量值（mmol/L），这是这些受试者中神经元活力、胞质胆碱和肌酸的假定标志物。与对照组相比，强迫症患者的左右内侧丘脑细胞质胆碱显著增加，但外侧丘脑没有。N-乙酰天冬氨酸和肌酸在内侧或外侧丘脑的病例对照对之间没有显着差异。这些发现为儿童强迫症患者丘脑中胞质胆碱异常提供了新的证据。
The thalamus has been implicated in the pathophysiology of obsessive-compulsive disorder. Using a multislice spectroscopic imaging sequence, we reported reductions in right and left medial thalamic N-acetylaspartate/cytosolic choline + creatine/phosphocreatine and N-acetylaspartate/cytosolic choline levels in 11 pediatric patients with obsessive-compulsive disorder, 8 to 15 years, versus 11 case-matched healthy controls. These changes may reflect a change in N-acetylaspartate, cytosolic choline, or creatine concentrations. Therefore, using a validated phantom replacement, methodology, we obtained absolute measures (mmol/L) of N-acetylaspartate, a putative marker of neuronal viability, cytosolic choline, and creatine in these subjects. A significant increase in cytosolic choline was observed in right and left medial but not lateral thalami in patients with obsessive-compulsive disorder versus controls. N-acetylaspartate and creatine did not differ significantly between case-control pairs in the medial or lateral thalamus. These findings provide new evidence of cytosolic choline abnormalities in the thalamus in pediatric obsessive-compulsive disorder.