Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes.
Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes.
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DOI：
10.3389/fmicb.2017.00546
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发表时间：
2017
影响因子：
5.2
通讯作者：
Berzal-Herranz A
中科院分区：
文献类型：
--
作者：
Fernández-Sanlés A;Ríos-Marco P;Romero-López C;Berzal-Herranz A
黄病毒属包含大量能够在某些节肢动物和/或脊椎动物宿主细胞的细胞质中复制的小的、正义单链RNA病毒。该属有大约70个成员物种，包括许多新出现和重新出现的病原体，这些病原体导致世界各地的人类疾病爆发，如西尼罗河病毒、登革热、寨卡病毒、黄热病、日本脑炎、圣路易斯脑炎和蜱传脑炎病毒。与其他RNA病毒一样，黄病毒有一个紧凑的RNA基因组，有效地储存了完成感染周期所需的所有信息。该存储系统的效率归因于超编码元件，即，具有基本功能的离散结构单元。这种信息存储系统与蛋白质编码序列重叠并互补，并且在整个属中高度保守。因此，它为新的治疗策略提供了有趣的潜在靶点。本文综述了黄病毒基因组功能RNA结构域的特征。它还提供了一个简要概述的主要成果，在抗病毒的核酸为基础的药物靶向功能基因组RNA元件的设计。
The genus Flavivirus comprises a large number of small, positive-sense single-stranded, RNA viruses able to replicate in the cytoplasm of certain arthropod and/or vertebrate host cells. The genus, which has some 70 member species, includes a number of emerging and re-emerging pathogens responsible for outbreaks of human disease around the world, such as the West Nile, dengue, Zika, yellow fever, Japanese encephalitis, St. Louis encephalitis, and tick-borne encephalitis viruses. Like other RNA viruses, flaviviruses have a compact RNA genome that efficiently stores all the information required for the completion of the infectious cycle. The efficiency of this storage system is attributable to supracoding elements, i.e., discrete, structural units with essential functions. This information storage system overlaps and complements the protein coding sequence and is highly conserved across the genus. It therefore offers interesting potential targets for novel therapeutic strategies. This review summarizes our knowledge of the features of flavivirus genome functional RNA domains. It also provides a brief overview of the main achievements reported in the design of antiviral nucleic acid-based drugs targeting functional genomic RNA elements.