Regional pattern of binding and c-Fos induction by (R)- and (S)-citalopram in rat brain
Regional pattern of binding and c-Fos induction by (R)- and (S)-citalopram in rat brain
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DOI：
10.1097/00001756-200312190-00024
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发表时间：
2003-12-19
期刊：
影响因子：
1.7
通讯作者：
Helboe, L
中科院分区：
文献类型：
--
作者：
Thomsen, C;Helboe, L
Citalopram is a racemic mixture of two stereoisomers, (R)- and (S)-citalopram. Both enantiomers were radiolabelled and used for in vitro receptor autoradiography in rat brain. High levels of specific [H-3](S)-citalopram binding were observed in the amygdala complex, substantia nigra, superior colliculus and central grey. No specific binding of [H-3](R)-citalopram was observed in any brain regions examined. S-citalopram induced a significant increase in c-Fos positive cells in central amygdala and in the bed nucleus of the stria terminalis (BST), compared to vehicle controls. A similar pattern of c-Fos activation was observed with (RS)-citalopram, sertraline and paroxetine, while (R)-citalopram did not increase c-Fos expression in these areas. The high affinity binding and apparent neuronal activation by (RS)-citalopram is thus confined to the (S)-enantiomer. (C) 2003 Lippincott Williams Wilkins.
