Norepinephrine but not epinephrine stimulates the release of corticotropin‐releasing factor from in vitro superfused rat hypothalamus
Norepinephrine but not epinephrine stimulates the release of corticotropin‐releasing factor from in vitro superfused rat hypothalamus
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去甲肾上腺素而非肾上腺素刺激体外灌注大鼠下丘脑释放促肾上腺皮质激素释放因子
DOI：
10.1002/jnr.490420211
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发表时间：
1995
影响因子：
4.2
通讯作者：
B. Kerdelhué
中科院分区：
文献类型：
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作者：
G. Orliaguet;S. Parsadaniantz;V. Lenoir;P. Duval;B. Kerdelhué
为了澄清关于儿茶酚胺能系统在调节下丘脑促肾上腺皮质激素释放因子（CRF）分泌中的作用的争议，我们评估了去甲肾上腺素和肾上腺素单独使用以及与混合α和β拮抗剂联合使用对下丘脑CRF分泌的直接影响。使用体外大鼠下丘脑内侧基底部灌流系统，通过特异性放射免疫测定法评价单个外植体的CRF分泌。我们发现去甲肾上腺素刺激CRF分泌，在10 - 8 M浓度下达到峰值效应，而肾上腺素对CRF分泌没有影响。去甲肾上腺素的作用可被混合α受体拮抗剂酚妥拉明和混合β受体拮抗剂普萘洛尔所拮抗。
To clarify the controversy concerning the role of catecholaminergic systems in regulating hypothalamic corticotropin‐releasing factor (CRF) secretion, we assessed the direct effects of norepinephrine and epinephrine, alone and in association with mixed α and β antagonists on hypothalamic CRF secretion. An in vitro rat mediobasal hypothalamus perifusion system was used, in which CRF secretion from a single explant was evaluated by a specific radioimmunoassay. We found that norepinephrine stimulated CRF secretion, with peak effects at 10‐8 M concentration, whereas epinephrine had no effect on CRF secretion. The effect of norepinephrine was antagonised by the mixed a antagonist phentolamine and by the mixed β antagonist propranolol.
促肾上腺皮质激素释放因子的测定。
影响因子：
--
作者：
Vale,W;Vaughan,J;Yamamoto,G;Bruhn,T;Douglas,C;Dalton,D;Rivier,C;Rivier,J
通讯作者：
Rivier,J