Synthesis and Anti-barnacle Activities of Novel Isocyanocyclohexane Compounds Containing an Ester or an Ether Functional Group
Synthesis and Anti-barnacle Activities of Novel Isocyanocyclohexane Compounds Containing an Ester or an Ether Functional Group
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DOI：
10.1080/0892701042000205334
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发表时间：
2004-04
期刊：
影响因子：
2.7
通讯作者：
Y. Kitano;Y. Nogata;Kyouji Shinshima;E. Yoshimura;K. Chiba;M. Tada;I. Sakaguchi
中科院分区：
文献类型：
--
作者：
Y. Kitano;Y. Nogata;Kyouji Shinshima;E. Yoshimura;K. Chiba;M. Tada;I. Sakaguchi
合成了10个4位含氧官能团的新型异氰环己烷类化合物，并评价了其对藤壶藤壶（Balanus amphitrite）幼虫的杀虫活性，旨在进一步探索构效关系。合成的化合物的抗藤壶效果在0.0096 - 17.0 μg ml-1的EC 50范围内。一些酯类衍生物表现出极高的杀虫活性，合成的异氰基环己烷化合物均未表现出明显的毒性。结果表明，酯官能团是异氰基化合物中表现强抗氧化活性的重要基团之一。
Ten novel isocyanocyclohexane compounds that possess an oxygenic functional group at the 4-position were synthesized and evaluated for their antifouling activity against the larvae of the barnacle Balanus amphitrite with the aim of exploring the structure – activity relationships further. The anti-barnacle effect of the synthesized compounds was in the EC50 range of 0.0096 – 17.0 μg ml−1. Some ester derivatives exhibited extremely high antifouling activities, and none of the synthesized isocyanocyclohexane compounds showed significant toxicity. The results suggest that the ester function is one of the important groups in the expression of potent antifouling activity in isocyano compounds.