Triglyceride Glucose Index and Related Parameters (Triglyceride Glucose-Body Mass Index and Triglyceride Glucose-Waist Circumference) Identify Nonalcoholic Fatty Liver and Liver Fibrosis in Individuals with Overweight/Obesity
Triglyceride Glucose Index and Related Parameters (Triglyceride Glucose-Body Mass Index and Triglyceride Glucose-Waist Circumference) Identify Nonalcoholic Fatty Liver and Liver Fibrosis in Individuals with Overweight/Obesity
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DOI：
10.1089/met.2020.0109
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发表时间：
2020-12-01
影响因子：
2.1
通讯作者：
Alaei-Shahmiri, Fariba
中科院分区：
文献类型：
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作者：
Khamseh, Mohammad E.;Malek, Mojtaba;Alaei-Shahmiri, Fariba
背景：甘油三酯葡萄糖（TyG）指数已被提议作为非酒精性脂肪性肝病（NAFLD）的可靠替代标志物。此外，NAFLD与肥胖密切相关。本研究旨在比较TyG指数及其相关参数（TyG-腰围[WC]和TyG-体重指数[BMI]），包括TyG和肥胖标志物，在预测NAFLD和肝纤维化的超重/肥胖个体无diabetes.Methods：这是一个横断面研究，包括184超重/肥胖的人（96与88没有NAFLD），30-65岁。使用已建立的公式计算TyG、TyG-BMI和TyG-WC。结果：在相关分析中，CAP和LSM与WC、BMI、TyG、TyG-BMI和TyG-WC显著相关。回归分析强调TyG-WC是NAFLD的重要预测因子，标准化比值比最高（2.25，P < 0.001）;而肝纤维化与TyG-BMI的相关性更强。在受试者工作特征（ROC）分析中，TyG-WC显示出NAFLD检测的ROC曲线下面积（AUC）最大（0.693，95%置信区间[CI]：0.617-0.769）。然而，TyG-BMI是肝纤维化的更好鉴别因素（AUC：0.635，95%CI：0.554-0.714）。TyG-WC值为876（敏感性：81.3%，特异性：52.3%）和TyG-BMI值为259（敏感性：78.3%，特异性：51.3%）分别是预测NAFLD和肝纤维化的最佳截断点。TyG-BMI和TyG-WC可以可靠地预测该人群中的肝纤维化。这些指标似乎是在临床环境中筛查NAFLD和肝纤维化的简单，实用和负担得起的工具。
Background: The triglyceride glucose (TyG) index has been proposed as a reliable surrogate marker for nonalcoholic fatty liver disease (NAFLD). Furthermore, NAFLD is strongly related with obesity. This study aimed to compare TyG index and its related parameters (TyG-waist circumference [WC] and TyG-body mass index [BMI]), comprising TyG and obesity markers, in predicting NAFLD and liver fibrosis in overweight/obese individuals without diabetes.Methods: This was a cross-sectional study consisting of 184 overweight/obese people (96 with and 88 without NAFLD), 30-65 years of age. TyG, TyG-BMI, and TyG-WC were computed using the established formula. Liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) were determined by transient elastography (FibroScan).Results: In correlation analyses, CAP and LSM were significantly associated with WC, BMI, TyG, TyG-BMI, and TyG-WC. Regression analyses highlighted TyG-WC as a significant predictor of NAFLD, with the highest standardized odds ratio (2.25, P < 0.001); while liver fibrosis was associated more strongly with TyG-BMI. In receiver operating characteristic (ROC) analysis, TyG-WC showed the largest area under the ROC curve (AUC) for detection of NAFLD (0.693, 95% confidence interval [CI]: 0.617-0.769). However, TyG-BMI was a better discriminator of liver fibrosis (AUC: 0.635, 95% CI: 0.554-0.714). TyG-WC value of 876 (sensitivity: 81.3%, specificity: 52.3%) and TyG-BMI value of 259 (sensitivity: 78.3%, specificity: 51.3%) were the optimal cutoff points to predict NAFLD and liver fibrosis, respectively.Conclusions: The results highlight the significant associations of TyG and its related indices with NAFLD, with TyG-WC being a better indicator. TyG-BMI and TyG-WC could reliably predict liver fibrosis in this population. These indices appear to be simple, practical, and affordable tools for screening NAFLD and liver fibrosis in clinical settings.