Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty
Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty
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DOI：
10.1080/000164700317411834
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发表时间：
2000-06-01
期刊：
影响因子：
--
通讯作者：
Fredin, H
中科院分区：
文献类型：
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作者：
Benoni, G;Lethagen, S;Fredin, H
我们对39例初次THR手术中氨甲环酸对术后失血量和输血量的影响进行了随机双盲研究。在手术结束时和3小时后给予氨甲环酸。1周后进行超声检查以测量深部血肿的发生率。与膝关节置换术中的宝贵发现相反，氨甲环酸的给药未能显著减少术后失血量。这种缺乏效果可能与药物给药太晚有关。在接受氨甲环酸的20例患者中，有11例不需要输血，安慰剂组中有4/19例（p = 0.05）。氨甲环酸组和安慰剂组术后深静脉血栓形成的发生率相似。
We performed a randomized double-blind study on the effect of tranexamic acid on postoperative blood loss and blood transfusions in 39 primary THR operations. Tranexamic acid was given at the end of the operation and 3 hours later. Ultrasound examination 1 week later was performed to measure the occurrence of deep hematomas.In contrast to precious findings in knee arthroplasty, the administration of tranexamic acid failed to give a significant reduction in the postoperative blood loss. This lack of effect was possibly related to the fact that the drug ass administered too late. In 11 of the 20 patients receiving tranexamic acid, blood transfusion was not necessary, this being the case in 4/19 in the placebo group (p = 0.05). The occurrence of postoperative deep venous thromboses was similar in the tranexamic acid and placebo groups.