Changes in oxidative stress markers in patients with schizophrenia: The effect of antipsychotic drugs
Changes in oxidative stress markers in patients with schizophrenia: The effect of antipsychotic drugs
复制标题
精神分裂症患者氧化应激标志物的变化：抗精神病药物的作用
DOI：
10.1016/j.psychres.2013.01.023
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发表时间：
2013
影响因子：
11.3
通讯作者：
Tiao
中科院分区：
文献类型：
--
作者：
Meng;C. Liou;Tsu;I. Lin;Tiao
本研究旨在探讨精神分裂症患者急性期血清氧化应激标志物的水平或活性，以及治疗前后超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽（GSH）和硫代巴比妥酸反应物质（TBARS）的变化。我们连续纳入41例急性期精神分裂症患者，并对其中27例患者进行为期4周的抗精神病药物治疗随访。血清氧化应激标志物测定试剂盒。精神分裂症急性期阳性与阴性症状量表（PANSS）总分与血清GPx活性、GSH水平呈显著负相关，与血清SOD活性呈正相关。此外，血清GPx活性与GSH水平呈正相关，与SOD活性呈负相关。急性期患者血清SOD活性与TBARS水平呈显著负相关。此外，我们发现只有在接受4周治疗的女性患者中GPx活性显著增加（P=0.006）。结果提示，SOD、GPX和GSH可作为精神分裂症急性期病情严重程度的指标。此外，抗精神病药物可能会影响接受4周治疗的女性患者的血清GPx活性。
The aim of this study was to investigate the serum levels or activities of oxidative stress markers in patients with schizophrenia in acute phase and evaluate the changes in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and thiobarbituric acid-reactive substances (TBARS) after treatment. We consecutively enrolled 41 patients with schizophrenia in acute phase, and 27 patients were followed up with a 4-week antipsychotic treatment. Serum oxidative stress markers were measured with assay kits. We found that Positive and Negative Syndrome Scale (PANSS) total scores were significantly negatively correlated with serum GPx activity and GSH levels and positively correlated with serum SOD activity in patients with schizophrenia in acute phase. In addition, serum GPx activity had a positive correlation with GSH levels and negative correlation with SOD activity. We also found that serum SOD activity was significantly negatively correlated with TBARS levels in patients in acute phase. Furthermore, we found significantly increased changes only in GPx activity in female patients receiving the 4-week treatment (P=0.006). In conclusion, our results suggest that SOD, GPX and GSH might be indicators of schizophrenia severity in acute phase. Furthermore, antipsychotic drugs might affect serum GPx activity in female patients receiving the 4-week treatment.
新型抗精神病药物对大鼠脑神经元一氧化氮合酶的长期影响。
DOI：
10.1016/s1089-8603(02)00126-x
发表时间：
2002
期刊：
Nitric oxide : biology and chemistry
影响因子：
--
作者：
Tarazi,FrankI;Zhang,Kehong;Baldessarini,RossJ
通讯作者：
Baldessarini,RossJ
影响因子：
4.8
作者：
Parikh, V;Khan, MM;Mahadik, SP
通讯作者：
Mahadik, SP