Molecular Pathology and Biomarkers.
Molecular Pathology and Biomarkers.
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分子病理学和生物标志物。
DOI：
10.1159/000442121
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发表时间：
2016
影响因子：
--
通讯作者：
Stenman,Göran
中科院分区：
文献类型：
--
作者：
Ha,PatrickK;Stenman,Göran
唾液腺肿瘤生物学的领域是相当广泛的，鉴于许多亚型的良性和恶性肿瘤起源于大唾液腺和小唾液腺。关于这些病变的分子病理学知识仍然有限，并且几乎没有临床上有用的诊断和预后生物标志物。然而，最近发现的某些关键基因组改变，如染色体易位，拷贝数改变和突变，这些病变的分子发病机制提供了新的见解，并可能有助于更好地定义它们。人们也希望这些新知识可以帮助指导治疗，但这种翻译的发展有些缓慢，可能是由于这些肿瘤的罕见性和缺乏大型随机研究。然而，由于手术和放射治疗的局限性，迫切需要了解这些肿瘤的致癌机制，以便合理选择化疗和/或靶向治疗。
The field of salivary gland tumor biology is quite broad, given the numerous subtypes of both benign and malignant tumors originating from the major and minor salivary glands. Knowledge about the molecular pathology of these lesions is still limited, and there are few clinically useful diagnostic and prognostic biomarkers. However, recent discoveries of certain key genomic alterations, such as chromosome translocations, copy number alterations, and mutations, provide new insights into the molecular pathogenesis of these lesions and may help to better define them. It is also hoped that this new knowledge can help to guide therapy, but this translation has been somewhat slow to develop, perhaps due to the rarity of these tumors and the lack of large, randomized studies. However, because of the limitations inherent in what surgery and radiation can provide, there is an urgent need for understanding of the mechanisms of carcinogenesis in these tumors individually, so that chemotherapy and/or targeted therapy can be rationally selected.