Signaling specificity by frizzled receptors in Drosophila
Signaling specificity by frizzled receptors in Drosophila
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DOI：
10.1126/science.288.5472.1825
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发表时间：
2000-06-09
期刊：
影响因子：
56.9
通讯作者：
Mlodzik, M
中科院分区：
文献类型：
--
作者：
Boutros, M;Mihaly, J;Mlodzik, M
Wnt-Frizzled（Fz）信号通路在脊椎动物和无脊椎动物的发育和体内平衡过程中发挥着重要作用。Fz受体可以通过β-连环蛋白依赖性和非依赖性途径进行信号传导。在果蝇中，Fr和Fz 2是Wg的冗余受体。此外，Fz通过不同的途径传递信号，以组织上皮结构的平面极化。我们证明了Fz 2和Fz的胞质序列分别优先激活β-连环蛋白和平面极性级联。这两种受体都激活两种途径，但效率不同。在密切相关的受体中信号传导效率的内在差异可能是体内产生信号传导特异性的一般机制。
Wnt-Frizzled (Fz) signaling pathways play recurring important roles during the development and homeostasis of vertebrates and invertebrates. Fz receptors can signal through beta-catenin-dependent and -independent pathways. In Drosophila, Fr and Fz2 are redundant receptors for Wg. In addition, Fz conveys signals through a distinct pathway to organize planar polarization of epithelial structures. We demonstrate that the cytoplasmic sequences of Fz2 and Fz preferentially activate the beta-catenin and planar polarity cascade, respectively. Both receptors activate either pathway, but with different efficiencies. Intrinsic differences in signaling efficiency in closely related receptors might be a general mechanism for generating signaling specificity in vivo.