Dissemination of International Clone II Acinetobacter baumannii Strains Coproducing OXA-23 Carbapenemase and 16S rRNA Methylase ArmA in Athens, Greece
Dissemination of International Clone II Acinetobacter baumannii Strains Coproducing OXA-23 Carbapenemase and 16S rRNA Methylase ArmA in Athens, Greece
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DOI：
10.1089/mdr.2019.0075
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发表时间：
2019-08-08
影响因子：
2.6
通讯作者：
Souli, Maria
中科院分区：
文献类型：
--
作者：
Nafplioti, Konstantina;Galani, Irene;Souli, Maria
本研究的目的是研究来自希腊雅典医院的产16 S rRNA甲基化酶（RMT）鲍曼不动杆菌临床分离株的分子流行病学。单一患者A.对来自5家三级医院的对阿米卡星和庆大霉素共耐药的鲍曼不动杆菌临床分离株（n = 347）进行最小抑菌浓度测定和碳青霉烯酶和RMT基因的分子检测。A.鲍曼不动杆菌对丁胺卡那霉素和庆大霉素耐药，在参与机构中的平均分离率为67.8%。其中93.7%的人携带有阿尔马。绝大多数（98.5%）阿尔马阳性分离株为OXA-23生产者，主要（99.4%）分配至序列组G1，对应于国际克隆（IC）II。4株分离株（均来自同一家医院）为OXA-24产生菌（1.2%），分配至G6，对应于CC 78，仅1株分离株为OXA-58产生菌，分配至G2（IC I）。安普霉素是抑制99.7%的菌株的最有效的药物，
The aim of this study was to study the molecular epidemiology of 16S rRNA-methylase (RMT)-producing clinical Acinetobacter baumannii isolates from hospitals in Athens, Greece. Single-patient A. baumannii clinical isolates, coresistant to amikacin and gentamicin (n = 347), from five tertiary care hospitals, were submitted to minimum inhibitory concentration determination and molecular testing for carbapenemase and RMT genes. A. baumannii, resistant to amikacin and gentamicin, was isolated at participating institutions at a mean rate of 67.8%. Among them 93.7% harbored the armA. The vast majority (98.5%) of armA positive isolates were OXA-23 producers, assigned mainly (99.4%) to sequence group G1, corresponding to international clone (IC) II. Four isolates (all from the same hospital) were OXA-24 producers (1.2%), assigned to G6 corresponding to CC78 and only one isolate was OXA-58-producer, assigned to G2 (IC I). Apramycin was the most active agent inhibiting 99.7% of the isolates at