Double-Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration
Double-Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration
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DOI：
10.1002/adma.201601030
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发表时间：
2016-08-17
影响因子：
29.4
通讯作者：
Gong, Jian Ping
中科院分区：
文献类型：
--
作者：
Nonoyama, Takayuki;Wada, Susumu;Gong, Jian Ping
将羟基磷灰石矿化的坚韧水凝胶植入兔子的骨软骨缺损中后，由于水凝胶的半渗透性，成骨作用会自发地渗透到凝胶基质中。梯度层（约 40 μm 厚）有助于凝胶与骨的牢固结合。这是首次成功实现坚韧水凝胶的稳健骨整合，且方法简单、实用可行。
On implanting hydroxyapatite-mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates into the gel matrix owing to the semi-permeablility of the hydrogel. The gradient layer (around 40 mu m thick) contributes quite strong bonding of the gel to bone. This is the first success in realizing the robust osteointegration of tough hydrogels, and the method is simple and feasible for practical use.