Immune response to the 23-valent polysaccharide pneumococcal vaccine after the 7-valent conjugate vaccine in allogeneic stem cell transplant recipients: Results from the EBMT IDWP01 trial
Immune response to the 23-valent polysaccharide pneumococcal vaccine after the 7-valent conjugate vaccine in allogeneic stem cell transplant recipients: Results from the EBMT IDWP01 trial
复制标题
DOI：
10.1016/j.vaccine.2010.01.025
复制
发表时间：
2010-03-24
期刊：
影响因子：
5.5
通讯作者：
Ljungman, Per
中科院分区：
文献类型：
--
作者：
Cordonnier, Catherine;Labopin, Myriam;Ljungman, Per
目前干细胞移植（SCT）后主动免疫的建议包括从移植后3个月开始接种3剂7价肺炎球菌结合疫苗（PCV7），然后接种23价多糖肺炎球菌疫苗（PPV23）。然而，到目前为止，SCT 后尚未评估 PCV7 后对 PPV23 的免疫反应。在 EBMT IDWP01 试验中，101 名患者在 12 或 18 个月时接受了 1 剂 PPV23，均是在 3 剂 PCV7 后接受的。移植后 1 个月和 24 个月时通过肺炎球菌血清型 1 和 5 抗体水平评估 PPV23 的功效。 PCV7 中不包括血清型 1 和 5。尽管在 PPV23 后 1 个月，两种抗原的几何平均浓度显着较高，但无论评估日期如何，各组之间的响应率 (>= 0.15 μg/mL) 在 68-94% 范围内没有差异。在 3 剂 PCV7 剂量后注射 1 剂 PPV23 已知可增加对 PCV7 的反应，也可扩大移植后 12 或 18 个月的血清型覆盖范围。 (C) 2010 Elsevier Ltd. 保留所有权利。
The current recommendations for active immunization after stem cell transplant (SCT) include 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7) from 3 months after transplant, followed by a 23-valent polysaccharide pneumococcal vaccine (PPV23). However, until now, the immune response to PPV23 after PCV7 has not been assessed after SCT. In the EBMT IDWP01 trial, 101 patients received 1 dose of PPV23 at 12 or 18 months, both after 3 doses of PCV7. The efficacy of PPV23 was assessed 1 month later and at 24 months after transplant by the pneumococcal serotype 1 and 5 antibody levels. Serotype 1 and 5 are not included in PCV7. Although the geometric mean concentrations were significantly higher 1 month after PPV23, for both antigens, the response rates (>= 0.15 mu g/mL), in the range of 68-94%, were not different between groups independent of the assessment date. One PPV23 dose after 3 PCV7 doses, already known to increase the response to PCV7, also extends the serotype coverage given 12 or 18 months after transplant. (C) 2010 Elsevier Ltd. All rights reserved.