MEMORY IMPAIRMENT AND DEPRESSION IN PATIENTS WITH LYME ENCEPHALOPATHY - COMPARISON WITH FIBROMYALGIA AND NONPSYCHOTICALLY DEPRESSED-PATIENTS
MEMORY IMPAIRMENT AND DEPRESSION IN PATIENTS WITH LYME ENCEPHALOPATHY - COMPARISON WITH FIBROMYALGIA AND NONPSYCHOTICALLY DEPRESSED-PATIENTS
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DOI：
10.1212/wnl.42.7.1263
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发表时间：
1992-07-01
期刊：
影响因子：
9.9
通讯作者：
STEERE, AC
中科院分区：
文献类型：
--
作者：
KAPLAN, RF;MEADOWS, ME;STEERE, AC
莱姆病脑病主要表现为记忆、情绪和睡眠障碍，是莱姆病常见的晚期神经系统表现。我们使用加州语言学习测验、韦氏记忆量表、Rey-Osterrieth复杂图形测验、明尼苏达多相人格调查表（MMPI）和贝克抑郁量表对20例莱姆病脑病患者、11例纤维肌痛患者和11例非精神病性抑郁患者进行了比较。与纤维肌痛或抑郁症患者相比，莱姆病组在三项记忆测试中的两项上表现出轻度但具有统计学意义的记忆缺陷。相比之下，纤维肌痛患者在MMPI量表上对躯体问题最敏感（量表1）的得分显著高于其他两组，而抑郁患者在量表上对抑郁（量表2）和焦虑（量表7）最敏感的得分高于莱姆患者。身体不适和抑郁不是影响莱姆病患者记忆表现的主要因素。这些数据支持莱姆病是由中枢神经系统功能障碍引起的假设，不能解释为对慢性疾病的心理反应。
Lyme encephalopathy, primarily manifested by disturbances in memory, mood, and sleep, is a common late neurologic manifestation of Lyme disease. We compared 20 patients with Lyme encephalopathy with 11 fibromyalgia patients and 11 nonpsychotically depressed patients using the California Verbal Learning Test, Wechsler Memory Scale, Rey-Osterrieth Complex Figure Test, Minnesota Multiphasic Personality Inventory (MMPI), and Beck Depression Inventory. Compared with patients with fibromyalgia or depression, the Lyme encephalopathy group showed mild, but statistically significant, memory deficits on two of the three memory tests. In contrast, the patients with fibromyalgia scored significantly higher than both other groups on the MMPI scale most sensitive to somatic concerns (scale 1), while the depressed patients scored higher than the Lyme patients on the scales most sensitive to depression (scale 2) and anxiety (scale 7). Physical complaints and depression were not major factors in memory performance among Lyme patients. These data support the hypothesis that Lyme encephalopathy is caused by CNS dysfunction and cannot be explained as a psychological response to chronic illness.