Pressor doses of angiotensin II increase insulin-mediated glucose uptake in normotensive men.
Pressor doses of angiotensin II increase insulin-mediated glucose uptake in normotensive men.
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血管紧张素 II 的升压剂量可增加血压正常男性中胰岛素介导的葡萄糖摄取。
DOI：
10.1152/ajpendo.1993.265.3.e362
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
DiPette,DJ
中科院分区：
文献类型：
--
作者：
Townsend,RR;DiPette,DJ
在血压正常的男性中，静脉注射加压剂量的血管紧张素II对胰岛素介导的葡萄糖摄取的影响被确定。在14名血压正常的受试者中使用3小时高胰岛素正糖钳来测定胰岛素介导的葡萄糖摄取，无论是否输注血管紧张素II（约15 ng.kg-1）。min-1)，使血压升高20/15 mmHg（收缩压/舒张压）。与单独使用胰岛素相比，添加血管紧张素II使全身葡萄糖摄取增加15% (9.2 +/- 0.5 vs. 10.8 +/- 0.8 mg.kg-1 x min-1, P = 0.011)，葡萄糖氧化（通过间接量热法测定）增加25% （4.0 +/- 0.3 vs. 4.9 +/- 0.4 mg.kg-1 x min-1, P < 0.05）。血管紧张素II输注期间，肝糖输出量无显著增加（2.2 +/- 0.1 vs. 2.4 +/- 0.1 mg.kg-1 x min-1; P = NS）。我们得出结论，加压剂量的血管紧张素II增加胰岛素介导的葡萄糖处理和氧化。其机制可能涉及血管紧张素II输注期间血液流向骨骼肌的重定向或血管紧张素II的直接生化作用。尽管研究对象是瘦血压正常的受试者，但这些结果对血管紧张素II在与原发性高血压相关的胰岛素抵抗中的重要作用提出了质疑。
The effect of pressor doses of angiotensin II infused intravenously on insulin-mediated glucose uptake was determined in normotensive men. A 3-h hyperinsulinemic euglycemic clamp was employed in 14 normotensive subjects to determine insulin-mediated glucose uptake with or without an infusion of angiotensin II (approximately 15 ng.kg-1.min-1), which increased blood pressure by 20/15 mmHg (systolic/diastolic). Addition of angiotensin II increased whole body glucose uptake by 15% (9.2 +/- 0.5 vs. 10.8 +/- 0.8 mg.kg-1 x min-1; P = 0.011), and glucose oxidation (determined by indirect calorimetry) by 25% (4.0 +/- 0.3 vs. 4.9 +/- 0.4 mg.kg-1 x min-1; P < 0.05) over insulin alone. There was no significant increase in hepatic glucose output during angiotensin II infusion (2.2 +/- 0.1 vs. 2.4 +/- 0.1 mg.kg-1 x min-1; P = NS). We conclude that angiotensin II in pressor doses increases insulin-mediated glucose disposal and oxidation. The mechanism for this may involve a redirection of blood flow into skeletal muscle during angiotensin II infusion or a direct biochemical action of angiotensin II. Although performed in lean normotensive subjects, these results cast doubt on a significant role for angiotensin II in the insulin resistance associated with essential hypertension.