Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress
Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress
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DOI：
10.1016/j.isci.2020.101232
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发表时间：
2020-06-26
期刊：
影响因子：
5.8
通讯作者：
Leulier, Francois
中科院分区：
文献类型：
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作者：
Consuegra, Jessika;Grenier, Theodore;Leulier, Francois
肠道微生物群在应激的营养环境中塑造动物的生长轨迹，但这种生理益处背后的分子机制仍然知之甚少。肠道微生物群主要由细菌组成，它们在自身之间以及与宿主之间构建代谢网络。到目前为止，微生物群的代谢活动如何促进寄主幼鱼的生长仍然未知。在这里，使用果蝇作为宿主模型，我们报告了它的两个主要细菌伙伴，植物乳杆菌和番茄醋杆菌，参与有益的代谢对话，促进宿主幼体生长，尽管营养压力。我们指出，植物乳杆菌产生的乳酸被pomorum用作额外的碳源，而pomorum为植物乳杆菌提供必需的氨基酸和维生素。这种细菌交叉喂养为宿主提供了一套合成代谢代谢物，可以在营养不良的情况下促进宿主的全身生长。
The gut microbiota shapes animal growth trajectory in stressful nutritional environments, but the molecular mechanisms behind such physiological benefits remain poorly understood. The gut microbiota is mostly composed of bacteria, which construct metabolic networks among themselves and with the host. Until now, how the metabolic activities of the microbiota contribute to host juvenile growth remains unknown. Here, using Drosophila as a host model, we report that two of its major bacterial partners, Lactobacillus plantarum and Acetobacter pomorum, engage in a beneficial metabolic dialogue that boosts host juvenile growth despite nutritional stress. We pinpoint that lactate, produced by L. plantarum, is utilized by A. pomorum as an additional carbon source, and A. pomorum provides essential amino acids and vitamins to L. plantarum. Such bacterial cross-feeding provisions a set of anabolicmetabolites to the host, which may foster host systemic growth despite poor nutrition.