Nonlinear Spatiotemporal Integration by Electrical and Chemical Synapses in the Retina.
Nonlinear Spatiotemporal Integration by Electrical and Chemical Synapses in the Retina.
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DOI：
10.1016/j.neuron.2016.03.012
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发表时间：
2016-04-20
期刊：
影响因子：
16.2
通讯作者：
Rieke F
中科院分区：
文献类型：
--
作者：
Kuo SP;Schwartz GW;Rieke F
电突触和化学突触共存于整个中枢神经系统的回路中。然而，目前还不清楚电和化学突触传递如何相互作用，以确定具有两种类型突触的网络的功能输出。我们发现，释放谷氨酸从双极细胞到视网膜神经节细胞（RGC）的强烈形状的缝隙连接介导的电耦合内的双极细胞网络的小鼠视网膜。具体来说，电突触传播信号横向双极细胞之间，这种横向传播有助于非线性增强双极细胞输出的视觉刺激，在空间和时间上密切。因此，我们的研究结果（1）突出了电和化学传输如何协同工作以影响网络输出，以及（2）揭示了一种以前未被认识到的电路机制，该机制增加了RGC对时空相关输入的敏感性，例如由运动产生的输入。Kuo等人，发现电突触传递和化学突触传递协同工作以控制视网膜ON锥双极细胞的谷氨酸释放。这种相互作用增强了视网膜神经节细胞对具有强时空相关性的视觉输入（如运动）的敏感性。
Electrical and chemical synapses coexist in circuits throughout the CNS. Yet, it is not well understood how electrical and chemical synaptic transmission interact to determine the functional output of networks endowed with both types of synapse. We found that release of glutamate from bipolar cells onto retinal ganglion cells (RGCs) was strongly shaped by gap junction-mediated electrical coupling within the bipolar cell network of the mouse retina. Specifically, electrical synapses spread signals laterally between bipolar cells, and this lateral spread contributed to a nonlinear enhancement of bipolar cell output to visual stimuli presented closely in space and time. Our findings thus (1) highlight how electrical and chemical transmission can work in concert to influence network output, and (2) reveal a previously unappreciated circuit mechanism that increases RGC sensitivity to spatiotemporally correlated input, such as that produced by motion. Kuo et al., find that electrical and chemical synaptic transmission work in concert to control glutamate release from retinal ON cone bipolar cells. This interaction enhances retinal ganglion cell sensitivity to visual inputs with strong spatiotemporal correlations, such as motion.