The diet-microbiota-metabolite axis regulates the host physiology.
The diet-microbiota-metabolite axis regulates the host physiology.
复制标题
DOI：
10.1093/jb/mvw022
复制
发表时间：
2016-07
影响因子：
2.7
通讯作者：
Takahiro Yamada;D. Takahashi;K. Hase
中科院分区：
文献类型：
--
作者：
Takahiro Yamada;D. Takahashi;K. Hase
肠道微生物群与多种疾病有关，包括炎症性肠病、肥胖和癌症。食物成分被认为是肠道微生物组成的主要决定因素，高脂肪饮食诱导的生态失调可以影响宿主生理。越来越多的研究表明，微生物代谢产物是肠上皮屏障和肠道免疫的关键调节剂。特别是，由细菌发酵的难消化的多糖产生的短链脂肪酸对肠道以外的宿主生理学具有深远的影响。在这篇综述中，我们描述了饮食-微生物群-代谢物轴对宿主生理的影响，特别是对免疫和代谢系统的影响。
The intestinal microbiota has been implicated in a wide range of diseases, including inflammatory bowel disease, obesity and cancer. Food ingredients are considered a major determinant of gut microbial composition, as exemplified by high-fat diet-induced dysbiosis that can affect host physiology. Accumulating studies show that microbial metabolites are key regulators of the intestinal epithelial barrier and gut immunity. In particular, short-chain fatty acids produced by bacterial fermentation of indigestible polysaccharides have profound impacts on host physiology beyond the gut. In this review, we describe the influences of the diet-microbiota-metabolite axis on host physiology, and especially on the immune and metabolic systems.