Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins.
Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins.
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山羊关节炎脑炎病毒、维斯纳病毒和进行性肺炎病毒之间的抗原交叉反应涉及所有病毒体相关蛋白和糖蛋白。
DOI：
10.1099/0022-1317-66-6-1233
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Cheevers,WP
中科院分区：
文献类型：
--
作者：
Gogolewski,RP;Adams,DS;McGuire,TC;Banks,KL;Cheevers,WP
对山羊关节炎-脑炎病毒、维斯纳病毒和进行性肺炎病毒的病毒粒子相关蛋白之间的抗原相关性进行了研究。抗原交叉反应性进行了评估，通过免疫沉淀的破坏，放射性标记的病毒与山羊，绵羊和兔抗血清，然后通过SDS-聚丙烯酰胺凝胶电泳的免疫沉淀产物的分辨率。结果表明，山羊和绵羊病毒分离株之间的抗原交叉反应性涉及所有主要的病毒体相关蛋白和糖蛋白。由病毒粒子结构蛋白展示的共同抗原决定簇在山羊、绵羊和兔中具有免疫原性。
Antigenic relatedness between the virion-associated proteins of caprine arthritis-encephalitis, visna and progressive pneumonia viruses was examined. Antigenic cross-reactivity was assessed by immunoprecipitation of disrupted, radiolabelled virus with goat, sheep and rabbit antisera, followed by resolution of the immunoprecipitation products by SDS-polyacrylamide gel electrophoresis. The results indicate that antigenic cross-reactivity between the caprine and ovine virus isolates involves all of the major virion-associated proteins and glycoproteins. The common antigenic determinants exhibited by virion structural proteins are immunogenic in goats, sheep and rabbits.