Radiation therapy has been shown to be adaptable for various stages of hepatocellular carcinoma
Radiation therapy has been shown to be adaptable for various stages of hepatocellular carcinoma
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DOI：
10.3748/wjg.v21.i1.94
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发表时间：
2015-01-07
影响因子：
4.3
通讯作者：
Shimosegawa, Tooru
中科院分区：
文献类型：
--
作者：
Kondo, Yasuteru;Kimura, Osamu;Shimosegawa, Tooru
除外科手术外，射频消融通常用于治疗大小和数量有限的肝细胞癌（HCC）。使用碘化罂粟籽油、碘油和抗癌药物的经导管动脉化疗栓塞术（TACE）已被积极用于治疗不可切除的HCC，特别是在亚洲国家。最近，索拉非尼可用于肝脏仍有足够功能的晚期HCC。索拉非尼是一种口服多激酶抑制剂，具有抗增殖和抗血管生成作用。然而，索拉非尼的作用似乎不足以控制HCC的进展。肝癌的放射治疗（RT）在肝癌的所有阶段都有潜在的作用。然而，在HCC共识文件或国家指南中，RT通常不被认为是一种选择，主要是因为支持证据不足。然而，由于技术的进步，RT的方法已经有了很大的改进。此外，RT联合其他治疗（TACE、索拉非尼、化疗等）已成为HCC的替代疗法之一。因此，我们应该了解各种类型的RT可用于HCC。本文就各种外照射放射治疗方法作一综述。
In addition to surgical procedures, radiofrequency ablation is commonly used for the treatment of hepatocellular carcinomas (HCCs) of limited size and number. Transcatheter arterial chemoembolization (TACE), using iodized poppy seed oil, Lipiodol and anticancer drugs, has been actively performed for the treatment of unresectable HCC, particularly in Asian countries. Recently, Sorafenib become available for advanced HCCs when the liver is still sufficiently functional. Sorafenib is an oral multikinase inhibitor with antiproliferative and antiangiogenic effects. However, the effect of sorafenib seems to be inadequate to control the progression of HCC. Radiation therapy (RT) for HCC has a potential role across all stages of HCC. However, RT is generally not considered an option in HCC consensus documents or national guidelines, primarily because of insufficient supporting evidence. However, the method of RT has much improved because of advances in technology. Moreover, combined treatment of RT plus other treatments (TACE, sorafenib and chemotherapy etc.) has become one of the alternative therapies for HCC. Therefore, we should understand the various kinds of RT available for HCC. In this review, we focus on various kinds of external beam radiation therapy.