Bioinformatics Applications Note Genetics and Population Analysis Varld: a Program for Quantifying Variation in Linkage Disequilibrium Patterns between Populations
Bioinformatics Applications Note Genetics and Population Analysis Varld: a Program for Quantifying Variation in Linkage Disequilibrium Patterns between Populations
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通讯作者：
Rick Twee-Hee;Ong;Y. Teo;Jeffrey Barrett
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作者：
Rick Twee-Hee;Ong;Y. Teo;Jeffrey Barrett
动机：群体间的连锁不平衡（LD）差异可能导致独立全基因组关联研究（GWAS）中无法复制性状关联的主要信号。然而，可以利用这种群体间LD差异来缩小对负责观察到的关联信号的常见因果变体的搜索。因此，评估和量化人群之间的LD变异的能力预计将有助于GWAS的复制和精细绘图阶段。可用性：程序varLD可从
Motivation: Linkage disequilibrium (LD) differences between populations can potentially result in failure to replicate primary signals of trait association in independent genome-wide association studies (GWAS). However, such inter-population LD differences can be leveraged to narrow the search for common causal variants responsible for the association signals observed. The ability to assess and quantify LD variations among populations is thus expected to contribute to both replication and fine-mapping stages of GWAS. Availability: The program varLD is available for download from