Encoding, consolidation, and retrieval of contextual memory:: Differential involvement of dorsal CA3 and CA1 hippocampal subregions
Encoding, consolidation, and retrieval of contextual memory:: Differential involvement of dorsal CA3 and CA1 hippocampal subregions
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DOI：
10.1101/lm.81905
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发表时间：
2005-07-01
影响因子：
2
通讯作者：
Lassalle, JM
中科院分区：
文献类型：
--
作者：
Daumas, S;Halley, H;Lassalle, JM
对人类和动物的研究揭示了海马体对关系记忆的独特贡献。然而，海马各亚区在记忆加工中的具体作用尚不清楚。海马的计算模型和理论强调了每个海马亚区在记忆中的独特功能，其中CA 3区充当所有的自联想记忆网络，而CA 1区作为关键的输出结构。为了了解CA 3-和CA 1-海马区在背景记忆形成中的各自作用，我们研究了利多卡因对背海马CA 3或CA 1区的可逆失活对背景恐惧条件反射的获取、巩固和检索的影响。而利多卡因的输注从来没有损害基本的音调条件反射，他们的影响油上下文条件反射提供了有趣的线索，这两个海马区的作用。他们首先证明了CA 3区域对于快速制定统一的上下文表示是必要的。第二，提示CA 1区参与了背景记忆的巩固过程。第三，他们表明，当使用再认记忆程序时，保持测试期间的CA 1或CA 3失活对情境恐惧提取没有影响。结论：背侧海马CA 1和CA 3亚区在情境恐惧记忆的获得和巩固过程中起着重要的作用，但在情境再认过程中并不起作用。
Studies on human and animals shed light On the unique hippocampus contributions to relational memory. However, the particular role of each hippocampal subregion in memory processing is still not clear. Hippocampal computational models and theories have emphasized a unique function in memory for each hippocampal subregion, with the CA3 area acting as all autoassociative memory network and the CA1 area as a critical Output structure. In order to understand the respective roles of the CA3- and CA1-hippocampal areas in the formation of contextual memory, we studied the effects of the reversible inactivation by lidocaine of the CA3 or CA1 areas of the dorsal hippocampus oil acquisition, consolidation, and retrieval of a contextual fear conditioning. Whereas infusions of lidocaine never impaired elementary tone conditioning, their effects oil contextual conditioning provided interesting clues about the role of these two hippocampal regions. They demonstrated first that the CA3 area is necessary for the rapid elaboration of a unified representation of the context. Secondly, they Suggested that the CA1 area is rather involved in the consolidation process of contextual memory. Third, they showed that CA1 or CA3 inactivation during retention test has no effect oil contextual fear retrieval when a recognition memory procedure is used. In Conclusion, our findings point as evidence that CA1 and CA3 subregions of the dorsal hippocampus play important and different roles in the acquisition and consolidation of contextual fear memory, whereas they are not required for context recognition.