Early growth and coronary heart disease and type 2 diabetes: findings from the Helsinki Birth Cohort Study (HBCS)
Early growth and coronary heart disease and type 2 diabetes: findings from the Helsinki Birth Cohort Study (HBCS)
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DOI：
10.3945/ajcn.110.000638
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发表时间：
2011-12-01
影响因子：
7.1
通讯作者：
Eriksson, Johan G.
中科院分区：
文献类型：
--
作者：
Eriksson, Johan G.
宫内生长缓慢是几种常见非传染性疾病的主要危险因素，包括：冠心病（CHD），高血压和2型糖尿病。同样，婴儿期和儿童期的生长模式已被确定为与这些疾病的发病机制相关的重要因素。在这篇综述中，根据1934-1944年赫尔辛基出生队列研究（HBCS）的结果，提出了与CHD、2型糖尿病和成年期相关代谢特征相关的生长模式。CHD的晚期风险与出生时和婴儿期的小体型有关，随后在儿童期体型增加。这种生长模式与晚年的血脂异常有关，这为观察到的结果提供了解释。2型糖尿病和冠心病有几个共同的危险因素。后来发展为2型糖尿病的人的早期生长包括出生时的小体型以及婴儿期的小体型。肥胖反弹的早期年龄与成年后患2型糖尿病的风险显著增加相关。与2型糖尿病相关的生长模式也与身体成分的改变有关，这容易导致胰岛素抵抗和代谢综合征。研究结果表明，为了能够了解几种非传染性疾病的发病机制，需要从生命过程的角度研究这些疾病，需要考虑到产前和儿童的成长以及成人的特点。美国临床营养杂志2011;94（增刊）：1799 S-802 S。
A slow rate of intrauterine growth is a major risk factor for several common noncommunicable diseases, which include the following: coronary heart disease (CHD), hypertension, and type 2 diabetes. Likewise, growth patterns in infancy and childhood have been identified as important factors linked to the pathogenesis of these disorders. In this overview, patterns of growth associated with CHD, type 2 diabetes, and related metabolic traits in adult life are presented on the basis of findings from the Helsinki Birth Cohort Study (HBCS) 1934-1944. Later risk of CHD was associated with small body size at birth and during infancy, followed by an increase in body size later in childhood. This pattern of growth has been associated with dyslipidemia in later life, which offers an explanation for the observed findings. Type 2 diabetes and CHD share several risk factors. The early growth of persons who later develop type 2 diabetes includes a small body size at birth as well as a small body size during infancy. An early age at adiposity rebound was associated with a markedly increased risk of type 2 diabetes in adulthood. The patterns of growth associated with type 2 diabetes are also associated with alterations in body composition, which predisposes to insulin resistance and the metabolic syndrome. The presented findings suggest that to be able to understand the pathogenesis of several noncommunicable diseases, the diseases need to be studied from a life-course perspective, and prenatal and childhood growth as well as adult characteristics need to be taken into account. Am J Clin Nutr 2011;94 (suppl):1799S-802S.