Introduction. A "neurovascular unit" approach in newborns with HIE: can we improve outcomes?
Introduction. A "neurovascular unit" approach in newborns with HIE: can we improve outcomes?
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介绍。
DOI：
10.1016/j.earlhumdev.2014.06.011
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发表时间：
2014
影响因子：
2.5
通讯作者：
Chalak,LinaF
中科院分区：
文献类型：
--
作者：
Chalak,LinaF
缺氧缺血性损伤引起的新生儿脑病仍然是一个重大的公共卫生问题，困扰着全世界数百万新生儿，并可能导致脑瘫、智力低下、学习障碍和死亡。 1 迫切需要了解这些窒息婴儿脑损伤的机制，以帮助指导未来的神经保护策略，因为尽管实施了低温治疗，但 50% 的婴儿仍然出现异常结果。 23, 4 概念上的“神经血管单元”依赖于完整的神经血管耦合，包括血管内皮细胞、星形胶质细胞、神经元以及支持神经胶质细胞，这些细胞都有助于脑血管功能的调节。 5, 6 该杂志的本期特刊重点关注神经血管单元，希望这种方法能够帮助优化未来 HIE 新生儿的预后。
Neonatal encephalopathy resul t ing f rom hypoxic-ischemic injury remains a major public health problem that afflicts millions of newborns worldwide and may result in cerebral palsy, mental retardation, learning disabilities, and death. 1 Understanding of the mechanisms that underlie cerebral injury in these asphyxiated infants is urgently needed to help guide future neuroprotective strategies, as 50% of infants continue to have abnormal outcomes despite implementation of hypothermia therapy. 23, 4 A conceptual ‘neurovascular unit’depends on intact neurovascular coupling an includes the vascular endothelial cells, astrocytes, neurons, as well as supporting glial cells, which all contribute to the regulation of cerebrovascular function. 5, 6 This special edition of the journal puts emphasis on the neurovascular unit, with the hopes that such approach can help optimize outcomes of newborns with HIE in the future.