Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidance
Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidance
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DOI：
10.1007/s004410050954
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发表时间：
1997-11-01
影响因子：
3.6
通讯作者：
Hirata, T
中科院分区：
文献类型：
--
作者：
Fujisawa, H;Kitsukawa, T;Hirata, T
神经菌素是一种细胞表面糖蛋白，最先在非洲爪哇蝌蚪神经组织中发现，随后在鸡和小鼠中发现。神经菌胶的一级结构在这些脊椎动物中高度保守。该分子的胞外部分由a1/a2、b1/b2和c三个结构域组成，每个结构域都被认为参与了分子和/或细胞的相互作用。神经粘连蛋白可以通过分子间的亲异相互作用来调节细胞间的黏附。在所研究的所有脊椎动物物种中，神经毛细蛋白蛋白仅限于特定神经元类别的轴突，并且在轴突生长活跃的阶段。在发育中的小鼠胚胎中，神经菌素功能的获得和丧失会导致神经纤维的脱屑和错误的发芽。这些发现表明，神经胶通过与多种分子结合，参与了多种神经细胞间的相互作用，并在神经纤维的束征和引导中发挥了重要作用。
Neuropilin is a cell-surface glycoprotein that was first identified in Xenopus tadpole nervous tissues and then in chicken and mouse. The primary structure of neuropilin is highly conserved among these vertebrate species. The extracellular part of the molecule is composed of three domains referred to as a1/a2, b1/b2, and c, each of which is expected to be involved in molecular and/or cellular interactions. Neuropilin can mediate cell adhesion by heterophilic molecular interaction. In all vertebrate species examined, the neuropilin protein is restricted to axons of particular neuron classes, and at stages when axon growth is active. The gain and loss of function of neuropilin in developing mouse embryos causes defasciculation and incorrect sprouting of nerve fibers. These findings suggest that neuropilin serves in a variety of neuronal cell interactions by binding to a variety of molecules, and that it plays essential roles in nerve fiber fasciculation and guidance.