Trends in ectopic pregnancy, hydatidiform mole and miscarriage in the largest obstetrics and gynaecology hospital in China from 2003 to 2013.
Trends in ectopic pregnancy, hydatidiform mole and miscarriage in the largest obstetrics and gynaecology hospital in China from 2003 to 2013.
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DOI：
10.1186/s12978-016-0181-5
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发表时间：
2016-05-20
影响因子：
3.4
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Li XL;Du DF;Chen SJ;Zheng SH;Lee AC;Chen Q
异位妊娠、流产和葡萄胎是妊娠早期病理性妊娠的主要类型，是一个重要的公共卫生问题。这些病理性妊娠的趋势和发生率可能因种族和地理区域而异。这在中国人群中还没有得到充分的调查。在本研究中，我们回顾性报道了中国人群中病理性妊娠的趋势。2003 - 2013年在中国最大的妇产科医院收集了22511例异位妊娠、葡萄胎和流产的数据。数据包括诊断时的年龄和每年诊断为异位妊娠、葡萄胎和流产的妇女人数。2013年宫外孕、葡萄胎、流产总数较2003年增加3.5倍。异位妊娠是病理性妊娠的主要形式，在病理性妊娠中流产的发生率较高。诊断为葡萄胎的女性中位年龄从25.5岁显著增加到29岁（p = 0.002），而其他病理性妊娠的中位年龄在2003年和2013年之间没有差异。诊断为葡萄胎的妇女年龄在40岁以上的人数有所增加。该院产妇的平均年龄从2003年的28.1岁增加到2013年的29.4岁。我们推测，产妇年龄的增加可能导致2003年至2013年中国病理性妊娠的增加。
Ectopic pregnancies, miscarriages and hydatidiform moles are the major types of pathological pregnancies in the early gestations of pregnancy and constitute an important public health problem. The trends and incidences of these pathological pregnancies may vary by ethnicity and geographical regions. This has not been fully investigated in the Chinese population. In this study we retrospectively report the trends of pathological pregnancies in Chinese population. Data on 22,511 women with ectopic pregnancy, hydatidiform mole and miscarriage were collected from the largest obstetrics and gynaecology hospital in China from 2003 to 2013. Data included age at diagnosis and the annual number of women with diagnosed ectopic pregnancy, hydatidiform mole and miscarriage. The total number of ectopic pregnancy, hydatidiform mole and miscarriage was increased 3.5folds in 2013 compared to 2003. Ectopic pregnancy is the leading pathological pregnancy and miscarriage is increasing at a greater rate among the pathological pregnancies. The median age of women with hydatidiform mole at diagnosis significantly increased from 25.5 years to 29 years (p = 0.002), however the median age for other pathological pregnancies was not different between 2003 and 2013. The number of women with hydatidiform mole at diagnosis who were over 40 years old has increased. The mean maternal age is increased from 28.1 years old in 2003 to 29.4 years old in 2013 in this hospital. We speculate that the increased maternal age may contribute to the increase in these pathological pregnancies between 2003 and 2013 in China.