Isolation and cloning of human peroxisome proliferator activated receptor gamma cDNA.
Isolation and cloning of human peroxisome proliferator activated receptor gamma cDNA.
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人过氧化物酶体增殖物激活受体γ cDNA 的分离和克隆。
DOI：
10.1007/978-1-4615-5325-0_37
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发表时间：
1997
影响因子：
--
通讯作者：
Nimer,SD
中科院分区：
文献类型：
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作者：
Greene,ME;Blumberg,B;Kwan,K;Hsieh,L;Greene,GL;Nimer,SD
核激素受体超家族蛋白是配体调节的转录因子，其直接将细胞转录反应与细胞外亲脂性信号传导化合物（例如类视色素、类固醇，以及可能的脂肪酸和花生四烯酸代谢物）联系起来（1）。这些受体调节主要的细胞过程，包括生殖、发育、稳态、分化和肿瘤发生（2）。视黄酸受体（RAR）、v-erb A和其他核受体与来自其他转录因子家族的蛋白质（例如fos和jun）具有重要的转录调节相互作用（3 - 5）。核受体还与其核激素受体超家族的其他成员具有显著的相互作用，例如类维生素A X受体（RXR）与RAR形成功能重要的异二聚体（6）。然而，RXR也可以在体外与许多不同的核激素受体异源二聚化，包括过氧化物酶体激活受体（PPARs）（7）。
The nuclear hormone receptor superfamily proteins are ligand modulated transcription factors that directly connect cellular transcriptional responses to extracellular lipophilic signalling compounds, such as retinoids, steroids, and perhaps fatty acid and arachidonic acid metabolites as well (1). These receptors regulate major cellular processes including reproduction, development, homeostasis, differentiation, and oncogenesis (2). Retinoic acid receptors (RARs), v-erb A, and other nuclear receptors have important transcription regulating interactions with proteins from other transcription factor families, for example fos and jun (3–5). Nuclear receptors also have significant interactions with other members of their nuclear hormone receptor superfamily, for example retinoid X receptors, (RXRs) form functionally important heterodimers with the RARs (6). RXRs, however, can also heterodimerize with a number of different nuclear hormone receptors in vitro, including the Peroxisome Proliferatior Activated Receptors, (PPARs) (7).