Effects of methadone plus alcohol on cognitive performance in methadone-maintained volunteers.
Effects of methadone plus alcohol on cognitive performance in methadone-maintained volunteers.
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DOI：
10.3109/00952990.2014.987348
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Mintzer MZ
中科院分区：
文献类型：
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作者：
Kleykamp BA;Vandrey RG;Bigelow GE;Strain EC;Mintzer MZ
美沙酮维持患者（MMP）经常滥用其他药物，包括酒精。美沙酮和酒精的联合使用可能会损害性能和日常功能。研究美沙酮与酒精结合以及美沙酮急性增加对绩效结果的影响。这项双盲、双模拟、交叉研究包括8名稳定接受美沙酮治疗的阿片类药物依赖参与者。参与者完成了6次住院治疗，对应于美沙酮（每日剂量的100%或150%）和饮料（安慰剂，0.25或0.50 g/kg酒精）。在给药前后完成性能任务。通过2（美沙酮剂量）× 3（酒精剂量）重复测量方差分析分析时间进程值下的面积。美沙酮的主要影响，观察两个注意力的结果，表明准确性降低，反应缓慢，在一个较高的美沙酮剂量。此外，观察到酒精对情景记忆的主要影响（假警报和反应偏差），这表明随着酒精剂量的增加，冲动反应增加。未观察到美沙酮和酒精之间的强烈相互作用。研究结果表明，美沙酮的急性增加（150%）和中等剂量的酒精（2-3杯）可以损害表现的不同方面，尽管没有发现美沙酮和酒精之间的显着相互作用。未来的研究具有更大的样本量，更大的剂量，更多的临床信息任务可以扩展目前的研究结果，并进一步探索阿片类药物和酒精并发的认知后果。使用.
Methadone maintenance patients (MMP) often abuse other drugs, including alcohol. The combined use of methadone and alcohol could impair performance and daily functioning. To examine the effects of methadone in combination with alcohol, as well as acute increases in methadone, on performance outcomes. This double blind, double-dummy, crossover study included 8 opioid dependent participants stabilized on methadone. Participants completed 6 inpatient sessions corresponding to methadone (100% or 150% of daily dose) and beverage (placebo, 0.25 or 0.50 g/kg alcohol). Performance tasks were completed before and after drug administration. Area under the timecourse values were analyzed by a 2 (methadone dose) by 3 (alcohol dose) repeated measures analysis of variance. Main effects of methadone were observed for two attention outcomes, suggesting reduced accuracy and slowed responding at an elevated methadone dose. In addition, main effects of alcohol were observed for episodic memory (false alarms and response bias) suggesting more impulsive responding as alcohol dose increased. No robust interactions of methadone and alcohol were observed for any outcome. Study findings indicate that an acute increase in methadone (150%) and a moderate dose of alcohol (2–3 drinks) can impair distinct aspects of performance, although no significant interactive effect between methadone and alcohol was found. Future studies with larger sample sizes, larger doses, and more clinically informative tasks could expand on the present findings and further explore the cognitive consequences of concurrent opioid and alcohol use.