Preparation and application of microfluidic SERS substrate: Challenges and future perspectives
Preparation and application of microfluidic SERS substrate: Challenges and future perspectives
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DOI：
10.1016/j.jmst.2019.06.018
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发表时间：
2020-01-15
影响因子：
10.9
通讯作者：
Ma, Xing
中科院分区：
文献类型：
--
作者：
Guo, Jiuchuan;Zeng, Fanyu;Ma, Xing
表面增强拉曼光谱(SERS)作为一种高灵敏度的分子分析技术，可以实现对分子键信息的快速、无损检测，通过指纹识别来识别被分析物的组成。SERS衬底的制备对SERS技术的发展和SERS检测的应用起着极其重要的作用。通过将SERS增强衬底集成到微流控芯片中，研究人员开发出了微流控SERS芯片，扩展了微流控芯片的功能，并配备了SERS技术强大的传感能力，为现场生化分析提供了一个高效的平台。本文首先对目前微流控SERS活性基板的制备技术进行了简要的综述，并对微流控SERS活性基板的应用前景进行了展望。然后指出了微流控SERS活性底物制备过程中面临的挑战，以及将该技术应用于生化应用的现实问题。(C)2019年由爱思唯尔有限公司代表《材料科学与技术杂志》编辑部出版。
Surface-enhanced Raman spectroscopy (SERS), as a highly sensitive molecular analysis technique, can realize fast and non-destructive detection of the information of molecular bonds to identify the component of analytes by "fingerprint" identification. The preparation of SERS substrates plays an extremely important role in the development of SERS technology and the application of SERS detection. By integrating SERS enhancement substrates into microfluidic chips, researchers have developed the microfluidic SERS chips which expand the function of microfluidic chips and provide an efficient platform for on-site biochemical analysis equipped with the powerful sensing capability of SERS technique. In this paper, we will first briefly give a review of the current microfluidic SERS-active substrates preparation technology and present the perspective on the application prospects of microfluidic SERS-active substrates. And then the challenges in the preparation of microfluidic SERS-active substrates will be pointed out, as well as realistic issues of using this technology for biochemical application. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.