A CTSA Agenda to Advance Methods for Comparative Effectiveness Research
A CTSA Agenda to Advance Methods for Comparative Effectiveness Research
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DOI：
10.1111/j.1752-8062.2011.00282.x
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发表时间：
2011-06-01
影响因子：
3.9
通讯作者：
Kent, David M.
中科院分区：
文献类型：
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作者：
Helfand, Mark;Tunis, Sean;Kent, David M.
临床研究需要对患者、临床医生和其他决策者更有用。为了满足这一需求，更多的研究应该关注以患者为中心的结果，比较可行的替代方案，并响应个体患者的偏好、需求、病理学、环境和价值观。这些特征使得比较有效性研究（CER）从根本上以患者为中心，挑战研究人员采用或开发提高临床研究的及时性、相关性和实际应用的方法。在本文中，我们描述了 10 个优先领域，满足以患者为中心的结果（PCOR）研究的 3 个关键需求：（1）开发和测试值得信赖的方法来识别和优先考虑重要的研究问题； (2) 改进临床研究的设计、实施和分析； (3) 将实际实践的过程和结果与以患者为中心的结果研究的优先事项联系起来。我们认为，美国国立卫生研究院应通过其临床和转化研究计划，将方法研究计划与其支持的更广泛的大型前瞻性临床和卫生系统研究联系起来，加速 CER 方法的开发和完善。这项工作产生的见解对于 PCORI 以及将资助和实施 CER 的广泛组织具有巨大价值。临床跨科学2011;第 4 卷：188-198
Clinical research needs to be more useful to patients, clinicians, and other decision makers. To meet this need, more research should focus on patient-centered outcomes, compare viable alternatives, and be responsive to individual patients' preferences, needs, pathobiology, settings, and values. These features, which make comparative effectiveness research (CER) fundamentally patient-centered, challenge researchers to adopt or develop methods that improve the timeliness, relevance, and practical application of clinical studies.In this paper, we describe 10 priority areas that address 3 critical needs for research on patient-centered outcomes (PCOR): (1) developing and testing trustworthy methods to identify and prioritize important questions for research; (2) improving the design, conduct, and analysis of clinical research studies; and (3) linking the process and outcomes of actual practice to priorities for research on patient-centered outcomes. We argue that the National Institutes of Health, through its clinical and translational research program, should accelerate the development and refinement of methods for CER by linking a program of methods research to the broader portfolio of large, prospective clinical and health system studies it supports. Insights generated by this work should be of enormous value to PCORI and to the broad range of organizations that will be funding and implementing CER. Clin Trans Sci 2011; Volume 4: 188-198