OCCURRENCE OF ANTIPERINUCLEAR, ANTIKERATIN, AND ANTI-RA-33 ANTIBODIES IN JUVENILE CHRONIC ARTHRITIS
OCCURRENCE OF ANTIPERINUCLEAR, ANTIKERATIN, AND ANTI-RA-33 ANTIBODIES IN JUVENILE CHRONIC ARTHRITIS
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DOI：
10.1136/ard.52.11.785
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发表时间：
1993-11-01
影响因子：
27.4
通讯作者：
MEYER, O
中科院分区：
文献类型：
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作者：
GABAY, C;PRIEUR, AM;MEYER, O
目的：抗核周因子(APF)、抗角蛋白抗体(AKA)和抗RA 33抗体目前被认为是诊断成人类风湿关节炎伴或不伴类风湿因子(RF)的良好标志物。我们回顾了幼年慢性关节炎儿童中这些标志物的流行情况，以确定它们是否与特定的特征有关。方法：124例幼年慢性关节炎患者参与本研究。对照组为28例青少年系统性红斑狼疮患者和21例健康儿童。采用间接免疫荧光法检测口腔黏膜细胞和食道切片中抗核周因子和AKA的含量。结果：抗核周因子在所有受试者中几乎不存在，仅在RF阳性的多关节起病患者中检测到抗RA 33抗体。抗角蛋白抗体出现在所有JCA儿童中的27%和RF阴性的多关节发病儿童中的42%。这些结果与健康对照组相比有统计学意义，但AKA的存在并不是任何患者亚组特有的。结论：APF、AKA和抗RA33抗体对JCA的诊断和分型没有意义。
Objectives-Antiperinuclear factor (APF), antikeratin antibodies (AKA), and anti-RA 33 antibodies are currently considered to be good markers for the diagnosis of adult rheumatoid arthritis with or without rheumatoid factor (RF). The prevalence of these markers was retrospectively reviewed in children with juvenile chronic arthritis (JCA) to determine whether they were associated with specific features.Methods-One hundred and twenty-four patients with JCA participated in this study. Controls included 28 patients with juvenile systemic lupus erythematosus and 21 healthy children. Antiperinuclear factor and AKA were determined by indirect immunofluorescence on buccal mucosal cells and oesophagus sections respectively. Anti-RA 33 antibodies were detected using a Western blot technique on HeLa cell nuclear extract.Results-Antiperinuclear factor was virtually absent in all the tested subgroups and anti-RA 33 antibodies were detected only in a subset of patients with RF positive polyarticular onset. Antikeratin antibodies were found in 27% of all children with JCA and in 42% of those with RF negative polyarticular onset. These results were statistically significant compared with healthy controls, but the presence of AKA was not specific to any patient subgroup. Moreover, in contrast with previous studies in adult RA, no relation was found between the presence of AKA and disease severity or activity.Conclusion-These data suggest that APF, AKA, and anti-RA 33 antibodies are not useful for the diagnosis or classification of JCA.