Activation and accumulation of B cells in TACI-deficient mice
Activation and accumulation of B cells in TACI-deficient mice
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DOI：
10.1038/89790
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发表时间：
2001-07-01
影响因子：
30.5
通讯作者：
Dixit, VM
中科院分区：
文献类型：
--
作者：
Yan, MH;Wang, M;Dixit, VM
肿瘤坏死因子（TNF）相关配体B淋巴细胞刺激因子（BLyS）结合两种TNF受体家族成员，即跨膜激活因子、钙调节和亲环蛋白配体相互作用因子（TACI）和B细胞成熟分子（BCMA）。BLyS转基因小鼠表现出细胞积聚、活化和自身免疫性狼疮样肾炎。至少两种不同BLyS受体的存在引起了每个受体对B细胞功能的相对贡献的问题。因此，我们产生了TACI缺陷的小鼠，TACI（-/-）小鼠显示出增加的细胞积累和显著的脾肿大。分离的TACI（-/-）B细胞在体外过度增殖并产生增加量的免疫球蛋白。体内抗原攻击导致增强的抗原特异性抗体产生。因此，TACI可能在细胞活化中发挥意想不到的抑制作用，有助于维持免疫稳态。
The tumor necrosis factor (TNF)-related ligand B lymphocyte stimulator (BLyS) binds two TNF receptor family members, transmembrane activator and calcium-modulating and cyclophilin ligand interactor (TACI) and B cell maturation molecule (BCMA). Mice that are transgenic for BLyS show a cell accumulation, activation and autoimmune lupus-like nephritis. The existence of at least two distinct BLyS receptors raises the question of the relative contribution of each to B cell functions. We therefore generated mice that were deficient in TACI, TACI(-/-) mice showed increased a cell accumulation and marked splenomegaly. isolated TACI(-/-) B cells hyperproliferated and produced increased amounts of immunoglobulins in vitro. In vivo antigen challenge resulted in enhanced antigen-specific antibody production. Thus, TACI may play an unexpected inhibitory role in a cell activation that helps maintain immunological homeostasis.