PET assessment of disease activity in children with juvenile idiopathic arthritis
PET assessment of disease activity in children with juvenile idiopathic arthritis
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DOI：
10.1007/s00247-010-1716-5
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发表时间：
2010-11-01
影响因子：
2.3
通讯作者：
Yokota, Shumpei
中科院分区：
文献类型：
--
作者：
Tateishi, Ukihide;Imagawa, Tomoyuki;Yokota, Shumpei
18-氟代脱氧葡萄糖(FDG)摄取的程度之前被报道与评估类风湿关节炎患者疾病活动性的体检和实验室测试有关。为了探讨青少年特发性关节炎(JIA)患者摄取F-18-FDG PET与疾病活动性的关系，对28例JIA患儿(平均5.4岁，1~16岁)进行了临床、生化和放射学检查。宠物图片由两位读者独立评估。我们研究了滑膜摄取F-18-FDG的程度与放射学、临床症状和实验室检查的关系。关节压痛和肿胀与关节异常摄取F-18-FDG呈正相关[优势比(OR)分别为5.37，7.12]。标准摄取值(SUV)max与中性粒细胞计数、血浆C反应蛋白(CRP)、血沉(ESR)、基质金属蛋白酶(MMP3)3呈正相关。关节糜烂(OR，6.17)、软组织肿胀(OR，3.77)、主要关节受累(OR，3.50)、压痛(OR，5.22)、血浆CRP浓度(OR，1.81)与SUVmax呈正相关。
The degree of 18-fluorodeoxyglucose (FDG) uptake is previously reported to correlate with physical examination and laboratory tests for evaluating disease activity in patients with rheumatoid arthritis. The clinical validity of F-18-FDG positron emission tomography (PET) has not been evaluated in juvenile idiopathic arthritis (JIA).To assess the relationship between F-18-FDG PET uptake and disease activity in children with JIA.A total of 560 joints in 28 children (mean age, 5.4 years; range, 1-16 years) with JIA who had undergone whole-body F-18-FDG PET before treatment were retrospectively assessed clinically, biochemically and radiographically. PET images were assessed independently by two readers. We investigated the relationships between the degree of synovial F-18-FDG uptake and radiographic and clinical symptoms and laboratory findings.Joint tenderness and swelling had a positive association with abnormal F-18-FDG uptake in the joint [odds ratio (OR) 5.37, 7.12, respectively]. The standardized uptake value (SUV) max correlated with the neutrophil count, plasma C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and matrix metalloproteinase (MMP) 3. Joint erosion (OR, 6.17), soft-tissue swelling (OR, 3.77), major joints involvement (OR, 3.50), tenderness (OR, 5.22), and CRP concentration in plasma (OR, 1.81) were positively associated with SUVmax.The degree of F-18-FDG uptake may be associated with the severity of synovitis in children with JIA.