Resource quality determines the evolution of resistance and its genetic basis.
Resource quality determines the evolution of resistance and its genetic basis.
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资源质量决定抗性的进化及其遗传基础。
DOI：
10.1111/mec.15621
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发表时间：
2020
影响因子：
4.9
通讯作者：
Roberts KE
中科院分区：
文献类型：
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作者：
Roberts KE
寄生虫对宿主有很强的选择性，但任何进化的抵抗力都可能受到资源可用性的限制。然而，确定这种资源介导选择的基因组基础的研究很少，特别是在非模式生物中。在这里，我们研究了营养在对DNA病毒（PiGV）的抗性进化中的作用，以及鳞翅目害虫物种（Plodia interpunctella）中的任何相关权衡。通过选择实验和全基因组重测序，我们确定了在选择过程中营养环境之间变化的抗性遗传标记。我们没有发现在病毒存在下一致的抗性进化，而是看到复制群体之间的实质性变化。低营养环境中的抗性与生长速度呈负相关，这与免疫和发育之间的既定权衡一致，但这种关系高度依赖于环境。宿主的全基因组重测序表明，抗性机制可能是高度多基因的，尽管高营养和低营养环境之间的潜在遗传结构可能不同，但通常使用类似的机制。总体而言，我们的研究结果强调了资源环境对影响抗性进化的重要性。
Parasites impose strong selection on their hosts, but the level of any evolved resistance may be constrained by the availability of resources. However, studies identifying the genomic basis of such resource‐mediated selection are rare, particularly in nonmodel organisms. Here, we investigated the role of nutrition in the evolution of resistance to a DNA virus (PiGV), and any associated trade‐offs in a lepidopteran pest species (Plodia interpunctella). Through selection experiments and whole‐genome resequencing, we identify genetic markers of resistance that vary between the nutritional environments during selection. We do not find consistent evolution of resistance in the presence of virus but rather see substantial variation among replicate populations. Resistance in a low‐nutrition environment is negatively correlated with growth rate, consistent with an established trade‐off between immunity and development, but this relationship is highly context dependent. Whole‐genome resequencing of the host shows that resistance mechanisms are likely to be highly polygenic and although the underlying genetic architecture may differ between high and low‐nutrition environments, similar mechanisms are commonly used. As a whole, our results emphasize the importance of the resource environment on influencing the evolution of resistance.