Structural investigation of spherical hollow excipient Mannit Q by X-ray microtomography.
Structural investigation of spherical hollow excipient Mannit Q by X-ray microtomography.
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DOI：
10.1016/j.ijpharm.2015.08.097
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发表时间：
2015-11
影响因子：
5.8
通讯作者：
Ryusuke Kajihara;Shuji Noguchi;Y. Iwao;Y. Yasuda;Megumi Segawa;S. Itai
中科院分区：
文献类型：
--
作者：
Ryusuke Kajihara;Shuji Noguchi;Y. Iwao;Y. Yasuda;Megumi Segawa;S. Itai
本文用同步辐射X射线显微断层扫描法研究了甘露醇溶液喷雾干燥制成的赋形剂Mannit Q微粒和Mannit Q片剂的结构。Mannit Q颗粒具有中空核的球形形状。颗粒的外壳由细小的针状晶体组成，中空部分为柱状晶体。这些结构特征表明空心粒子的形成机理是：在喷雾干燥过程中，溶剂从液滴表面迅速蒸发，形成由细小针状晶体组成的壳层，而留在壳层内的溶剂则缓慢蒸发，随着空心粒子的形成，更大的柱状晶体生长。虽然大多数Mannit Q颗粒在压片时被压碎，但一些颗粒保留了它们的中空结构，这可能是因为中空内的柱状晶体起着道具的作用。这表明，使用Mannit Q可以容易地制造具有多孔空隙空间的片剂。
The structure of Mannit Q particles, an excipient made by spray-drying ad-mannitol solution, and Mannit Q tablets were investigated by synchrotron X-ray microtomography. The Mannit Q particles had a spherical shape with a hollow core. The shells of the particles consisted of fine needle-shaped crystals, and columnar crystals were present in the hollows. These structural features suggested the following formation mechanism for the hollow particles:during the spray-drying process, the solvent rapidly evaporated from the droplet surface, resulting in the formation of shells made of fine needle-shaped crystals.Solvent remaining inside the shells then evaporated slowly and larger columnar crystals grew as the hollows formed. Although most of the Mannit Q particles were crushed on tableting, some of the particles retained their hollow structures, probably because the columnar crystals inside the hollows functioned as props. This demonstrated that the tablets with porous void spaces may be readily manufactured using Mannit Q.