In Utero Eye Development Documented by Fetal MR Imaging
In Utero Eye Development Documented by Fetal MR Imaging
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DOI：
10.3174/ajnr.a1664
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发表时间：
2009-10-01
影响因子：
3.5
通讯作者：
Panigrahy, A.
中科院分区：
文献类型：
--
作者：
Paquette, L. B.;Jackson, H. A.;Panigrahy, A.
背景和目的：迄今为止，对胎儿 MR 成像检测到的眼部异常或生长参数的关注非常有限。我们的目的是通过胎儿磁共振成像回顾性确定人类胎儿眼睛发育的不同参数与估计孕龄之间的关系。 材料和方法：进行回顾性研究，测量 127 个形态正常中枢神经系统胎儿的眼球横径、眼间距离和晶状体直径，使用 1.5T 磁铁获得多个单次 T2 快速自旋回波图像。至少 2 个正交平面内的连续 3 毫米间隔。拟合 Loess 曲线以探讨胎龄与 3 个感兴趣测量值之间的关系。对不同模型进行统计比较以确定最佳拟合模型。结果：对于每个感兴趣的变量，眼睛生长的“最佳”模型是二次函数。具体来说，晶状体生长似乎在妊娠 36 周后趋于稳定，眼距在妊娠 36 周后趋于稳定，眼球生长在妊娠 42 周后趋于稳定。 结论：胎儿的晶状体、眼眶和眼间距离生长可以在胎儿 MR 成像中得到证实。所有 3 次测量均表明生长的二次模型，表明妊娠末期生长减慢。
BACKGROUND AND PURPOSE: To date, very limited attention has been given to ocular abnormalities or growth parameters detected by fetal MR imaging. Our objective was to retrospectively determine the relationship between different parameters of eye development and estimated gestational age in the human fetus by use of fetal MR imaging.MATERIALS AND METHODS: A retrospective study was performed to measure the transverse diameter, interocular distance, and lens diameter of the globes of 127 fetuses who had a morphologically normal central nervous system, Multiple single-shot T2 fast spin-echo images were obtained with a 1.5T magnet by use of contiguous 3-mm intervals in at least 2 orthogonal planes. Loess curves were fitted to explore the relationship between gestational age and each of the 3 measurements of interest. Different models were compared statistically to determine the model of best fit.RESULTS: For each variable of interest, the "best" model of eye growth was a quadratic function. Specifically, lens growth seems to plateau after 36 weeks of gestation, interocular distance plateaus after 36 weeks of gestation, and globe growth plateaus after 42 weeks of gestation.CONCLUSIONS: The lens, orbit, and interocular distance growth of the fetus can be demonstrated on fetal MR imaging. All 3 measurements suggest a quadratic model of growth, which indicates slowing of growth toward the end of gestation.