A DNA polymerase alpha-associated 56 kDa protein kinase.
A DNA polymerase alpha-associated 56 kDa protein kinase.
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一种 DNA 聚合酶 α 相关的 56 kDa 蛋白激酶。
DOI：
10.1006/bbrc.1993.1051
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发表时间：
1993
影响因子：
3.1
通讯作者：
Cress,AE
中科院分区：
文献类型：
--
作者：
Peck,VM;Gerner,EW;Cress,AE
在细胞周期中，染色体DNA复制的起始必须仔细调节。我们报道了果蝇胚胎DNA聚合酶α复合物，通过免疫技术分离，含有蛋白激酶活性。该激酶会磷酸化组蛋白H1，但更倾向于DNA聚合酶α-激酶复合物中含有的肽。复性实验确定该激酶活性位于56-kDa肽中。
Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report thatDrosophilaembryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.