Mathematically guided approaches to distinguish models of periodic patterning
Mathematically guided approaches to distinguish models of periodic patterning
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DOI：
10.1242/dev.107441
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发表时间：
2015-02-01
期刊：
影响因子：
4.6
通讯作者：
Megason, Sean G.
中科院分区：
文献类型：
--
作者：
Hiscock, Tom W.;Megason, Sean G.
周期模式是如何产生的，这是一个悬而未决的问题。已经提出了许多机制--最著名的是图灵的反应扩散模型。然而，许多理论和实验研究都集中在图灵机制上，而忽略了其他可能的机制。在这里，我们使用周期图案的一般模型来说明不同类型的机制(分子、细胞、机械)可以产生定性上相似的最终图案。因此，观察最终模式不足以偏袒一种机制而不是其他机制。然而，我们认为数学方法可以帮助指导能够区分不同机制的实验的设计，并通过具体的生物学例子来说明这种方法的潜在价值。
How periodic patterns are generated is an open question. A number of mechanisms have been proposed - most famously, Turing's reaction-diffusion model. However, many theoretical and experimental studies focus on the Turing mechanism while ignoring other possible mechanisms. Here, we use a general model of periodic patterning to show that different types of mechanism (molecular, cellular, mechanical) can generate qualitatively similar final patterns. Observation of final patterns is therefore not sufficient to favour one mechanism over others. However, we propose that a mathematical approach can help to guide the design of experiments that can distinguish between different mechanisms, and illustrate the potential value of this approach with specific biological examples.