Fetal Microchimeric Cells Participate in Tumour Angiogenesis in Melanomas Occurring during Pregnancy
Fetal Microchimeric Cells Participate in Tumour Angiogenesis in Melanomas Occurring during Pregnancy
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DOI：
10.2353/ajpath.2009.080566
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发表时间：
2009-02-01
影响因子：
6
通讯作者：
Aractingi, Selim
中科院分区：
文献类型：
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作者：
Huu, Sau Nguyen;Oster, Michele;Aractingi, Selim
黑色素瘤是年轻人的主要恶性肿瘤，占妊娠相关肿瘤的8%。在怀孕期间，少量的胎儿细胞进入母体循环。这些细胞持续存在，然后迁移到各种母体组织，在那里它们可以移植和分化，特别是如果存在器官损伤，采用宿主器官的表型。为了了解黑色素瘤和怀孕之间的关系，我们分析了人类和小鼠的这些肿瘤。在妊娠期间63%的人类原发性黑色素瘤中检测到胎儿细胞，而在痣中为12%（P = 0.034），在妊娠小鼠的B16黑色素瘤中为57%，但在正常皮肤中从未检测到胎儿细胞（P = 0.000022）。超过50%的胎儿细胞表达CD 34、CD 31或血管性血友病因子内皮细胞标志物。此外，Lyve-1淋巴抗原在小鼠中超过30%的胎儿细胞中表达。总之，我们发现妊娠期的黑色素瘤经常含有具有内皮细胞表型的胎儿细胞。需要进一步的研究来评估胎儿对淋巴管生成的贡献是否可能改变母体肿瘤的预后。(Am J Pathol 2009，174：630-637; DOI：10.2353/ajpath.2009.080566）
Melanoma is a major malignancy in younger individuals that accounts for 8% of all neoplasias associated with gestation. During pregnancy, a small number of fetal cells enter the maternal circulation. These cells persist and then migrate to various maternal tissues where they may engraft and differentiate, particularly if there is organ damage, adopting the phenotype of the host organ. To understand the relationship between melanoma and pregnancy, we analyzed these tumors in both humans and mice. Fetal cells were detected in 63% of human primary melanomas versus 12% in nevi during pregnancy (P = 0.034) and in 57% of B16 melanomas in pregnant mice but never in normal skin (P = 0.000022). More than 50% of these fetal cells expressed the CD34, CD31, or von Willebrand factor endothelial cell markers. In addition, the Lyve-1 lymphatic antigen was expressed by more than 30% of fetal cells in mice. in conclusion, we show that melanomas during pregnancy frequently harbor fetal cells that have an endothelial phenotype. Further studies are needed to assess whether the fetal contribution to lymphangiogenesis may alter the prognosis of the maternal tumor.(Am J Pathol 2009,174:630-637; DOI: 10.2353/ajpath.2009.080566)