Multiple primary melanomas
Multiple primary melanomas
复制标题
DOI：
10.1067/mjd.2001.110878
复制
发表时间：
2001-01-01
影响因子：
13.8
通讯作者：
Bergman, W
中科院分区：
文献类型：
--
作者：
Stam-Posthuma, JJ;van Duinen, C;Bergman, W
目的：探讨增生性黑色素瘤发生的危险因素。方法：对56例黑色素瘤患者进行回顾性研究。结果：起病年龄早(58.9%)，临床诊断为增生性痣(82.0%)，组织学诊断为增生性黑色素瘤(%)，临床诊断为发育不良痣或黑色素瘤的家族史(70.8%)或黑色素瘤家族史(64.7%)以及组织学诊断的发育不良痣合并黑色素瘤家族史(48%)的患者比例较高。平均确诊年龄为38.2岁。第一次黑色素瘤和第二次黑色素瘤的平均间隔时间为34.3个月。在第二种黑色素瘤中，76.8%发生在与第一种黑色素瘤不同的解剖区域。肿瘤平均厚度(Breslow)从第一个黑色素瘤的1.11 mm下降到第二个黑色素瘤的0.90 mm。结论：黑色素瘤的早期和继发性发展可能与遗传因素有关。
Background: Patients with clinically diagnosed dysplastic nevi or 3 family history of melanoma with or without histologically diagnosed dysplastic nevi seem to be at higher risk For the development of multiple melanomas.Objective: Our purpose was to determine which factors increased the risk for the development of subsequent melanomas.Methods: This was a retrospective study in 56 patients with 157 melanomas.Results: Early age at onset (58.9%), clinically diagnosed dysplastic nevi (82.0%), a histologically diagnosed dysplastic nevus (64%), family history of clinically diagnosed dysplastic nevi (70.8%) or melanoma (64.7%) and a histologically diagnosed dysplastic nevus in combination with a family history of melanoma (48%) were found in a high percentage of patients. The mean age at diagnosis was 38.2 years. The mean interval between the first and second melanoma was 34.3 months. Of the second melanomas, 76.8% developed in a different anatomic region from the first melanomas. The mean tumor thickness (Breslow) decreased from 1.11 mm for the first melanomas to 0.90 mm for the second melanomas.Conclusion: The results suggest that genetic factors might he involved in a certain subset of patients in whom melanomas develop early and successively.