Engaging in an auditory task suppresses responses in auditory cortex.
Engaging in an auditory task suppresses responses in auditory cortex.
复制标题
DOI：
10.1038/nn.2306
复制
发表时间：
2009-05
影响因子：
25
通讯作者：
Zador, Anthony M.
中科院分区：
文献类型：
--
作者：
Otazu, Gonzalo H.;Tai, Lung-Hao;Yang, Yang;Zador, Anthony M.
尽管人们已经对涉及注意选择的系统进行了广泛的研究，但对非选择性系统的了解却少得多。为了研究这些准备机制，我们比较了听觉皮层的活动引起的声音，而大鼠进行听觉任务（“参与”）与活动引起的相同的刺激，而受试者是清醒的，但不执行任务（“被动”）。令人惊讶的是，我们发现参与抑制反应，这种效果与选择性注意引起的反应相反。然而，在听觉丘脑，参与增强自发放电率，但不影响诱发反应。这些结果表明，在听觉皮层，神经活动不能被简单地看作是一个有限的资源分配在更大的措施，作为动物的状态从嗜睡到被动地听，从事和专注。相反，忙碌状态具有一种独特的神经信号，在这种信号中，声音诱发的反应被矛盾地抑制了。
Although systems involved in attentional selection have been studied extensively, much less is known about non-selective systems. To study these preparatory mechanisms, we compared activity in auditory cortex elicited by sounds while rats performed an auditory task (“engaged”) with activity elicited by identical stimuli while subjects were awake but not performing a task (“passive”). Surprisingly, we found that engagement suppressed responses, an effect opposite in sign to that elicited by selective attention. In the auditory thalamus, however, engagement enhanced spontaneous firing rates but did not affect evoked responses. These results demonstrate that in auditory cortex, neural activity cannot be viewed simply as a limited resource allocated in greater measure as the state of the animal passes from somnolent to passively listening to engaged and attentive. Instead the engaged condition possesses a characteristic and distinct neural signature in which sound-evoked responses are paradoxically suppressed.
登录
查看更多内容
影响因子：
2.5
作者：
Hirata, A;Castro-Alamancos, MA
通讯作者：
Castro-Alamancos, MA
影响因子：
9.8
作者：
Hromádka T;Deweese MR;Zador AM
通讯作者：
Zador AM
影响因子：
56.9
作者：
HUBEL, DH;HENSON, CO;GALAMBOS, R
通讯作者：
GALAMBOS, R
影响因子：
25
作者：
Kawai, Hideki;Lazar, Ronit;Metherate, Raju
通讯作者：
Metherate, Raju
影响因子：
2.9
作者：
HOCHERMAN, S;BENSON, DA;HEINZ, RD
通讯作者：
HEINZ, RD