DO SEIZURES IN CHILDREN CAUSE INTELLECTUAL DETERIORATION
DO SEIZURES IN CHILDREN CAUSE INTELLECTUAL DETERIORATION
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DOI：
10.1056/nejm198604243141705
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发表时间：
1986-04-24
影响因子：
158.5
通讯作者：
NELSON, KB
中科院分区：
文献类型：
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作者：
ELLENBERG, JH;HIRTZ, DG;NELSON, KB
我们研究儿童时期癫痫发作是否影响智力表现。在一项大型纵向研究中，我们将经历过一次或多次非发热性癫痫发作的七岁儿童的全面智商与没有癫痫发作的同龄兄弟姐妹的智商进行了比较。在98名癫痫患儿中，7岁时智商测试的平均得分与其兄弟姐妹的平均得分没有显著差异。精神发育迟滞在癫痫发作的儿童中更为常见，但在第一次癫痫发作之前就有神经系统异常的儿童占了更多的比例。我们还检测了62名儿童癫痫发作前后的智商，这些儿童的第一次癫痫发作发生在4岁到7岁之间进行的心理测试之间。癫痫发作儿童七岁时的智商与智商（在四年的评估中确定）、性别、种族和社会经济地位相匹配的对照组没有显著差异。因此，在兄弟姐妹与对照组的比较中，以及在癫痫发作前后对照与受试者之间的比较中，非发热性癫痫发作的发生与全面智商的显著变化无关。
We studied whether the occurrence of seizures in childhood affected intellectual performance. We compared the full-scale IQs at seven years of age of children who had experienced one or more nonfebrile seizures with the IQs of their seizure-free siblings who were tested at the same age in a large longitudinal study. Among 98 children with seizures, the mean score on IQ tests at seven years was not significantly different from the mean score of their siblings. Mental retardation was more common among the children with seizures, but the excess was accounted for by children who had neurologic abnormalities before the first seizure. We also examined the IQ before and after the onset of seizures in 62 children whose first seizure occurred in the interval between psychometric examinations given at four and seven years of age. The IQ at seven years in the children with seizures did not differ significantly from that in controls matched for IQ (as determined at the four-year assessment), sex, race, and socioeconomic status. Thus, in both the sibling-control comparison and the comparisons made between controls and subjects before and after the onset of seizures, the occurrence of nonfebrile seizures was not associated with a significant change in full-scale IQ.