Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study
Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study
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DOI：
10.1007/s10552-010-9582-x
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发表时间：
2010-10-01
影响因子：
2.3
通讯作者：
Van Guelpen, Bethany
中科院分区：
文献类型：
--
作者：
Nilsson, Lena Maria;Johansson, Ingegerd;Van Guelpen, Bethany
尽管过滤咖啡和煮咖啡之间可能存在相关的化学差异，但这项研究是第一次调查饮用咖啡与患癌症风险之间的关系。研究对象来自Vasterbotten干预项目（64,603名参与者，包括3,034例病例），随访时间长达15年。采用多变量Cox回归计算风险比（HR）。在所有癌症部位、前列腺癌或结直肠癌中均未发现相关性。对于乳腺癌来说，煮咖啡每千日元1份与每天喝1次相比，风险降低（HR = 0.52, CI = 0.30-0.88, p（趋势）= 0.247）。总的（hr绝经前= 1.69,CI = 0.96-2.98, p（趋势）= 0.015，hr绝经后= 0.60,CI = 0.39-0.93, p（趋势）= 0.006）和过滤咖啡（hr绝经前= 1.76,CI = 1.04-3.00, p（趋势）= 0.045，hr绝经后= 0.52,CI = 0.30-0.88, p（趋势）= 0.045）均发现绝经前乳腺癌风险增加和绝经后乳腺癌风险降低。煮咖啡与患呼吸道癌的风险呈正相关（HR = 1.81, CI = 1.06-3.08, p（趋势）= 0.084），这一发现仅限于男性。不常见癌症类型的主要结果包括：全咖啡在肾细胞癌中的作用（HR = 0.30, CI = 0.11-0.79, p（趋势）= 0.009）和煮咖啡在胰腺癌中的作用（HR = 2.51, CI = 1.15-5.50, p（趋势）= 0.006）。这些发现首次证明了冲泡方法在咖啡消费和癌症风险调查中的潜在相关性，但它们必须在未来的研究中得到证实。
Despite potentially relevant chemical differences between filtered and boiled coffee, this study is the first to investigate consumption in relation to the risk of incident cancer.Subjects were from the Vasterbotten Intervention Project (64,603 participants, including 3,034 cases), with up to 15 years of follow-up. Hazard ratios (HR) were calculated by multivariate Cox regression.No associations were found for all cancer sites combined, or for prostate or colorectal cancer. For breast cancer, boiled coffee a parts per thousand yen4 versus < 1 occasions/day was associated with a reduced risk (HR = 0.52, CI = 0.30-0.88, p (trend) = 0.247). An increased risk of premenopausal and a reduced risk of postmenopausal breast cancer were found for both total (HRpremenopausal = 1.69, CI = 0.96-2.98, p (trend) = 0.015, HRpostmenopausal = 0.60, CI = 0.39-0.93, p (trend) = 0.006) and filtered coffee (HRpremenopausal = 1.76, CI = 1.04-3.00, p (trend) = 0.045, HRpostmenopausal = 0.52, CI = 0.30-0.88, p (trend) = 0.045). Boiled coffee was positively associated with the risk of respiratory tract cancer (HR = 1.81, CI = 1.06-3.08, p (trend) = 0.084), a finding limited to men. Main results for less common cancer types included total coffee in renal cell cancer (HR = 0.30, CI = 0.11-0.79, p (trend) = 0.009) and boiled coffee in pancreas cancer (HR = 2.51 CI = 1.15-5.50, p (trend) = 0.006).These findings demonstrate, for the first time, the potential relevance of brewing method in investigations of coffee consumption and cancer risk, but they must be confirmed in future studies.