Role of oxygen in limiting respiration in the in situ myocardium.
Role of oxygen in limiting respiration in the in situ myocardium.
复制标题
氧气在限制原位心肌呼吸中的作用。
DOI：
10.1006/jmcc.1998.0823
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Jue,T
中科院分区：
文献类型：
--
作者：
Kreutzer,U;Mekhamer,Y;Tran,TK;Jue,T
1H NMR现在已经从心肌原位检测到近端组氨酸NδH肌红蛋白（Mb）信号。在多巴胺输注80 μg/kg/min时，心率压积（RPP）增加2倍，磷酸肌酸（PCr）减少17%，无机磷酸盐与PCr变化的比值（ΔPi/PCr）增加0.2倍。然而，未检测到脱氧肌红蛋白信号。在多巴胺增强的心肌工作状态下，氧可用性似乎并不限制氧消耗和氧化磷酸化。
1H NMR has now detected the proximal histidyl NδH myoglobin (Mb) signal from the myocardiumin situ. Upon ligation of the left anterior descending coronary artery in the rat myocardium, the deoxy Mb signal appears at 78 ppm During dopamine infusion at up to 80 μg/kg/min, the heart rate pressure product (RPP) increases by a factor of 2, the phosphocreatine (PCr) decreases by 17%, and the ratio of the change in inorganic phosphate over PCr (ΔPi/PCr) increases by 0.2. However, no deoxy myoglobin signal is detected. Oxygen availability does not appear to limit oxygen consumption nor oxidative phosphorylation under dopamine enhanced work state in myocardium.