Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT.
Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT.
复制标题
使用软件套件基因研究阐明转录控制和顺式调节代码。
DOI：
10.1186/gb-2006-7-10-r97
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发表时间：
2006
期刊：
影响因子：
12.3
通讯作者：
中科院分区：
文献类型：
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作者：
描述了一种新的软件套件GENEACT，用于从DNA微阵列数据中检测差异表达基因中进化保守的转录因子结合位点或microRNAs。破译基因调控网络需要系统地识别顺式作用的功能调控元件。我们提出了一套基于网络的生物信息学工具，称为GeneACT，它可以快速检测进化上保守的转录因子结合位点或microRNA靶点，这些位点在DNA微阵列数据的差异表达基因中是唯一的或过度表达的。GeneACT提供了图形可视化和提取启动子和3‘-非翻译区的共同调控序列元件，这些启动子和3’-非翻译区在多种哺乳动物物种中保守。
GENEACT, a new software suite for the detection of evolutionarily conserved transcription factor binding sites or microRNAs from differentially expressed genes from DNA microarray data, is described. Deciphering gene regulatory networks requires the systematic identification of functional cis-acting regulatory elements. We present a suite of web-based bioinformatics tools, called GeneACT , that can rapidly detect evolutionarily conserved transcription factor binding sites or microRNA target sites that are either unique or over-represented in differentially expressed genes from DNA microarray data. GeneACT provides graphic visualization and extraction of common regulatory sequence elements in the promoters and 3'-untranslated regions that are conserved across multiple mammalian species.