Mecamylamine attenuates ephedrine-induced hyperactivity in rats
Mecamylamine attenuates ephedrine-induced hyperactivity in rats
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DOI：
10.1016/j.pbb.2005.03.008
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发表时间：
2005-05-01
影响因子：
3.6
通讯作者：
Segert, IL
中科院分区：
文献类型：
--
作者：
Miller, DK;Segert, IL
麻黄碱是一种中枢神经系统兴奋剂，其药理学特征与安非他明相似。麻黄素急性给药后诱导大鼠活动过度，重复给药后对麻黄素产生运动致敏作用。最近的研究表明，烟碱受体（nAChRs）发挥的作用，在发展中的运动致敏D-苯丙胺和本研究的目标是确定是否nAChRs同样介导急性和反复注射药物后的麻黄碱的影响。在连续12天，用nAChR拮抗剂美加明（0.3 - 3.0 mg/kg）或盐水预处理大鼠，然后注射（-）-麻黄碱（10 - 30 mg/kg）或盐水，并测量自发活动。麻黄碱产生了剂量依赖性的增加自发活动，并致敏麻黄碱开发与重复注射。美加明预处理减弱了重复注射麻黄碱（10 mg/kg）产生的活动过度和致敏作用，但对急性注射麻黄碱无影响。在较高的麻黄碱剂量（30 mg/kg）下，克服了美加明的抑制作用。目前的结果表明，nAChRs在麻黄碱运动致敏的发展中发挥着介导作用。(C)2005年爱思唯尔公司All rights reserved.
Ephedrine is a central nervous system stimulant that has a pharmacological profile similar to amphetamines. Ephedrine induces hyperactivity after acute administration to rats and locomotor sensitization develops to ephedrine with repeated administration. Recent research suggests that nicotinic receptors (nAChRs) play a role in the development of locomotor sensitization to D-amphetamine and the goal of the present study was to determine if nAChRs similarly mediate the effects of ephedrine after acute and repeated drug injection. On 12 consecutive days, rats were pretreated with the nAChR antagonist mecamylamine (0.3-3.0 mg/kg) or saline followed by (-)-ephedrine (10-30 mg/kg) or saline injection and locomotor activity was measured. Ephedrine produced a dose-dependent increase in locomotor activity, and sensitization to ephedrine developed with repeated injection. Mecamylamine pretreatment attenuated the hyperactivity and sensitization produced by repeated, but not acute, ephedrine (10 mg/kg) injection. The inhibitory effect of mecamylamine was overcome at the higher ephedrine dose (30 mg/kg). The present results indicate that nAChRs play a mediating role in the development of locomotor sensitization to ephedrine. (C) 2005 Elsevier Inc. All rights reserved.