LTP maintenance and its protein synthesis-dependence
LTP maintenance and its protein synthesis-dependence
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DOI：
10.1016/j.nlm.2007.10.001
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发表时间：
2008-03-01
影响因子：
2.7
通讯作者：
Williams, Joanna M.
中科院分区：
文献类型：
--
作者：
Abraham, Wickliffe C.;Williams, Joanna M.
长期增强（LTP）的特性以许多有趣的方式反映了联想记忆的特性。尽管单突触连接的可塑性不能解释分布式记忆的各种微妙特征，但重要的是要确定它们之间的相似之处可以画到什么程度。在这里，我们简要地讨论了LTP的特性，如其持续时间、可逆性、存储和再巩固是否与相应的记忆现象有关。然后，我们讨论LTP稳定是否实际上需要蛋白质合成，因为这在最近受到了挑战，就像长期记忆巩固中蛋白质合成的必要性被质疑一样。我们得出的结论是，即使合成蛋白的特性及其对LTP过程的贡献尚未完全了解，蛋白质合成在LTP稳定中仍然发挥着必要的作用。然而，我们强调了可以有效地进行研究的领域，以进一步了解LTP的性质和蛋白质合成依赖性。(C) 2007爱思唯尔公司版权所有。
The properties of long-term potentiation (LTP) mirror those of associative memory in a number of interesting ways. Although plasticity at monosynaptic connections is not expected to account for the varied subtle characteristics of distributed memories, nonetheless it is important to establish how far the parallels can be drawn. Here, we briefly address whether properties of LTP such as its duration, reversibility, savings and reconsolidation relate to corresponding memory phenomena. We then address whether LTP stabilization in fact requires protein synthesis, as this has been challenged in recent times much like the necessity for protein synthesis in the consolidation of long-term memory has been queried. We conclude that the case is still very strong for a necessary role of protein synthesis in LTP stabilization, even though the identities of the synthesized proteins and their contributions to the LTP process are not fully understood. However, we highlight areas of research that could be usefully conducted to further our understanding of the properties and protein synthesis-dependence of LTP. (C) 2007 Elsevier Inc. All rights reserved.